Epidermal abrasion device with isotropically etched tips, and method of fabricating such a device

• US 6,187,210 B1
• Filed: 06/29/1998
• Issued: 02/13/2001
• Est. Priority Date: 06/30/1997
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Pisano, Albert P., Lebouitz, Kyle S.
• Primary Examiner(s): Mills, Gregory
• Assistant Examiner(s): POWELL, ALVA C
• Application Number:
  US09/106,991
• Time in Patent Office: 960 Days
• Field of Search: 604/187, 216/2, 216/11, 216/39, 216/56, 216/99, 438/52, 438/53, 438/745, 438/753
• US Class Current: 216/11
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/296 for electromyography [EMG]
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/685 Microneedles

Abstract

A probe includes an elongated body with a top surface, a bottom surface, a first side wall between the top surface and the bottom surface, and a second side wall between the top surface and the bottom surface. An end is defined by the bottom surface converging into a tip, an isotropically etched portion of the first side wall converging into the tip, and an isotropically etched portion of the second side wall converging into the tip. The elongated body is less than approximately 700 μm wide and less than approximately 200 μm thick. The elongated body may incorporate a fluid channel. The elongated body may be formed of silicon that is not doped with Boron. In such a configuration, integrated circuitry or a micromachined device, such as a heater or pump may also be formed on the device. A number of novel processing techniques are associate with the fabrication of the device. The device may be formed by relying solely on isotropic etching. Alternately, a combination of isotropic and anisotropic etching may be used. Unlike prior art micromachined devices, the disclosed device may be processed at relatively low temperatures below 1100° C. and without using the carcinogen ethylenediamin pyrocatechol.

Claims

1. A method of fabricating an epidermal abrasion device, said method comprising the steps of:

providing a semiconductor substrate with a planar surface;

defining a mask configuration on said semiconductor substrate to facilitate the formation of an epidermal abrasion device; and

exposing said mask configuration on said semiconductor substrate to an isotropic etchant, said isotropic etchant forming a matrix of isotropically etched structures on said semiconductor substrate adapted for epidermal abrasion, said isotropically etched structures having isotropically etched sidewalls positioned between wide bases and narrow tips;

wherein said exposing step includes forming a matrix of isotropically etched pyramids on said semiconductor substrate.

2. The method of claim 1 further comprising the step of using a phosphosilicate glass layer to facilitate formation of said matrix of isotropically etched pyramids on said semiconductor substrate.

3. The method of claim 1 wherein each said structure has a vertical height of between 20 μ

m and 350 μ

m.

4. The method of claim 1 wherein horizontal spacing between tops of adjacent ones of said isotropically etched structures is greater than two times the vertical height of each adjacent structure.

5. The method of claim 1 wherein said providing step includes providing a silicon on-insulator (SOI) wafer as said semiconductor substrate.

6. The method of claim 1 wherein said exposing step is performed without the use of ethylenediamine pyrocatechol.

7. A method of fabricating an epidermal abrasion device, said method comprising the steps of:

providing a semiconductor substrate with a planar surface;

defining a mask configuration on said semiconductor substrate to facilitate the formation of an epidemial abrasion device; and

exposing said mask configuration on said semiconductor substrate to an isotropic etchant, said isotropic etchant forming a matrix of isotropically etched structures on said semiconductor substrate adapted for epidermal abrasion, said isotropically etched structures having isotropically etched sidewalls positioned between wide bases and narrow tips;

wherein said exposing step includes exposing said mask configuration on said semiconductor substrate to an isotropic etchant to form said matrix of isotropically etched structures in which each structure has a vertical height of at least 20 μ

m.

8.The method of claim 7 wherein each said structure has a vertical height of between 20 μ

m and 350 μ

m.

8. The method of claim 8 wherein horizontal spacing between tops of adjacent ones of said isotropically etched structures is greater than two times the vertical height of each adjacent structure.

9. The method of claim 8 wherein said providing step includes the step of providing a silicon on-insulator (SOI) wafer as said semiconductor substrate.

10. The method of claim 8 wherein said exposing step is performed without the use of ethylenediamine pyrocatechol.