Sonophoretic enhanced transdermal transport
First Claim
1. A method for enhanced transport of a molecule into or through skin, comprising the steps:
- permeabilizing the skin by applying low frequency ultrasound to the area of the skin where permeabilization is desired, wherein the frequency of the ultrasound is between about 20 kHz and 1 MHz;
subsequently applying a driving force to extract analyte molecules through or to deliver drug molecules into the skin over a period of time following the permeabilization without repermeabilizing the skin.
6 Assignments
0 Petitions
Accused Products
Abstract
Methods for enhanced transdermal transport wherein the application of ultrasound is required only once for repeated or sustained transdermal extraction or delivery, over a period of time, rather than prior to each extraction or delivery. The method is applicable to analyte extraction, as well as for drug delivery. The method involves the initial application of an amount of low frequency ultrasound effective to permeabilize the skin or membrane followed by analyte extraction or drug delivery over a period of time. The initial application of ultrasound is effective to permeabilize the skin or membrane for at least about 30 minutes, preferably at least one to two hours, and more preferably up to four to ten hours. The ultrasound is preferably low frequency ultrasound, less than 2.5 MHz, more preferably less than 1 MHz. The transdermal transport can be enhanced by the application of a secondary driving force such as suction, osmotic pressure gradient, concentration gradient, iontophoresis, electroporation, magnetic field, additional ultrasound, or mechanical pressure.
313 Citations
13 Claims
-
1. A method for enhanced transport of a molecule into or through skin, comprising the steps:
-
permeabilizing the skin by applying low frequency ultrasound to the area of the skin where permeabilization is desired, wherein the frequency of the ultrasound is between about 20 kHz and 1 MHz;
subsequently applying a driving force to extract analyte molecules through or to deliver drug molecules into the skin over a period of time following the permeabilization without repermeabilizing the skin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
Specification