Methods and apparatus for inactivating contaminants in biological fluid
First Claim
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1. Apparatus for treating a biological fluid with light comprising:
- a light chamber defined by at least two pair of facing, reflective walls wherein each of said pair of walls substantially defines a compound parabolic curve;
a high intensity light source disposed within said chamber; and
a fluid treatment region exterior to said light chamber, said fluid treatment region adapted to hold a quantity of biological fluid.
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Abstract
Apparatus and methods for treating a biological fluid with light and for inactivating contaminants in biological fluid. The biological fluid is contacted with a light source providing a high intensity light to the biological fluid. The biological fluid may include a quantity of a photochemical agent that when activated by light is operable to cause inactivation of at least some of the contaminants.
132 Citations
29 Claims
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1. Apparatus for treating a biological fluid with light comprising:
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a light chamber defined by at least two pair of facing, reflective walls wherein each of said pair of walls substantially defines a compound parabolic curve;
a high intensity light source disposed within said chamber; and
a fluid treatment region exterior to said light chamber, said fluid treatment region adapted to hold a quantity of biological fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 28)
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8. A method for substantially inactivating contaminants in a biological fluid comprising:
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providing a quantity of a biological fluid;
combining said biological fluid with a selected amount of a phenothiazine dye whereby the concentration of said phenothiazine dye is between approximately 2-4 μ
M; and
contacting said combination of biological fluid and phenothiazine dye with a high intensity light of greater than about 30 mW/cm2. - View Dependent Claims (9, 10, 11, 12, 13, 14, 29)
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15. Apparatus for inactivating contaminants in a biological fluid comprising:
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a first high intensity light source for providing light having an intensity of between approximately 80-150 mW/cm2 in the wavelength range of between approximately 550-700 nm;
a second high intensity light source for providing light having an intensity of between approximately 80-150 mW/cm2 in the wavelength range of between approximately 550-700 nm; and
a fluid treatment region located between said first and second light sources, wherein each of said light sources is separated from said fluid treatment region by a window which substantially transmits light in said wavelength range but does not substantially transmit selected unwanted light. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification