Stabilized thyroxine medications

• US 6,190,696 B1
• Filed: 06/07/1999
• Issued: 02/20/2001
• Est. Priority Date: 06/08/1998
• Status: Expired due to Fees

• Current Assignee: Groenewoud, Pieter J.
• Original Assignee: Groenewoud, Pieter J.
• Inventors: Groenewoud, Pieter J.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): CHANNAVAJJALA, LAKSHMI SARADA
• Application Number:
  US09/327,256
• Time in Patent Office: 624 Days
• Field of Search: 424/464, 424/465, 424/475, 514/5
• US Class Current: 424/464
• CPC Class Codes: A61K 9/2009 Inorganic compounds
• CPC Class Codes: A61K 9/2054 Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

Thyroxine medications which include combinations of levothyroxine, and/or liothronine, or dextrothyroxine, or thyroid, and one or more iodine salts, or iodine donor compounds are described, which produce a stable thyroxine medication, with a long shelf life. A method for manufacturing the medications is also described.

Claims

1. A method of making stabilized thyronine medications by combining together

(a) Liothyronine Sodium

(b) at least one iodine salt mixed with a carrier

(c) a disintegrant

(d) a lubricant

(e) a binder, and

(f) a filler.

2. A method of making stabilized thyroxine medications as defined in claim 1 with the additional step of

combining levothyroxine sodium with said liothyronine sodium.

7. A method of making stabilized thyroid medications as defined in claims 1 or 3 by combining a antioxidant.

8. A method of making stabilized thyroid medications as defined in claims 1, 2, 3, or 4, wherein the medications are packaged in a high barrier container, and an antioxidant is added to the medications after they have been formed, which antioxidant is held serarately from the medications in a small container.

3. A method of making a stabilized thyroxine medication by combining together

(a) Dextrothyroxine Sodium

(b) at least one iodine salt

(c) a disintegrant

(d) a lubricant

(e) a binder, and

(f) a filler.

4. A stabilized thyroxine medication consisting of the combination of

Levothyroxine Sodium,

Liothyronine Sodium and

at least one iodine salt.

5. A method of making stabilized thyroxine medications by combining together

(a) thyroid

(b) at least one iodine salt

(c) a disintegrant

(d) a lubricant

(e) a binder and

(f) a filler.

6. A method of making stabilized form of lithyronine sodium raw material by combining together:

(d) Liothyronine sodium

(e) A carrier material

(f) Sodium iodide or other sutable iodide compound.