Systems and methods for removing viral agents from blood
First Claim
1. A system for treating plasma that is essentially free of red blood cells and includes a first cellular blood species, a second cellular blood species and is different than the first cellular blood species, and an extracellular viral agent, the system comprisingtubing adapted to be coupled to a source of the plasma, a first filtration media coupled to the tubing to separate the first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate the second cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essential free of red blood cells, the first cellular blood species, and the second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, and a photoactive material to be mixed with the filtered plasma to bind to the extracellular viral agent and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
6 Assignments
0 Petitions
Accused Products
Abstract
System and methods treat plasma carrying contaminants and cellular matter that are capable of entraining contaminants. The systems and methods separate cellular matter from the plasma by filtration, thereby removing contaminants entrained within the cellular matter. The system and methods add to the plasma a photoactive material. The systems and methods emit radiation at a selected wavelength into the plasma to activate the photoactive material and thereby eradicate the contaminant that is free of entrainment by cellular matter.
134 Citations
63 Claims
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1. A system for treating plasma that is essentially free of red blood cells and includes a first cellular blood species, a second cellular blood species and is different than the first cellular blood species, and an extracellular viral agent, the system comprising
tubing adapted to be coupled to a source of the plasma, a first filtration media coupled to the tubing to separate the first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate the second cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essential free of red blood cells, the first cellular blood species, and the second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, and a photoactive material to be mixed with the filtered plasma to bind to the extracellular viral agent and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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17. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, and a photoactive material to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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22. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, a photoactive material comprising methylene blue to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum, and an overwrap enveloping the transfer container, the overwrap being made of a light filtering material including phthalocyanine pigments to absorb the light energy.
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24. A system for treating plasma that is essentially free of red blood cells and includes a first cellular blood species, a second cellular blood species and is different than the first cellular blood species, and an extracellular viral agent, the system comprising
tubing adapted to be coupled to a source of the plasma, a first filtration media coupled to the tubing to separate the first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate the second cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essential free of red blood cells, the first cellular blood species, and the second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing also including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, and a photoactive material to be mixed with the filtered plasma to bind to the extracellular viral agent and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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28. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container to the plasma source in a path that bypasses the first and second filtration media, and a photoactive material to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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29. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, the path including a one way valve that blocks fluid flow in a direction toward the transfer container while permitting fluid flow in a direction away from the transfer container, and a photoactive material to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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30. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, an air reservoir communicating with the path, and a photoactive material to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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31. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, and a photoactive material contained within the transfer container to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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32. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, a photoactive material to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum and the transfer container includes a material that is essentially transparent to the light energy.
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33. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, a photoactive material to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum, and an overwrap enveloping the transfer container, the overwrap being made of a light filtering material that absorbs the light energy.
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37. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container made of a material that accommodates plasma storage, the transfer container being coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, and a photoactive material to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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38. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, the tubing including a path to vent air from the transfer container in a path that bypasses the first and second filtration media, an auxiliary container separate from the transfer container, and a photoactive material in the auxilary container to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
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42. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, a photoactive material contained within the transfer container comprising methylene blue to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum, and an overwrap enveloping the transfer container, the overwrap being made of a light filtering material including phthalocyanine pigments to absorb the light energy.
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44. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, an auxiliary container separate from the transfer container, a photoactive material contained within the auxiliary container comprising methylene blue to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum, and an overwrap enveloping the transfer container, the overwrap being made of a light filtering material including phthalocyanine pigments to absorb the light energy.
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46. A system for treating plasma comprising
tubing adapted to be coupled to a plasma source, a first filtration media coupled to the tubing to separate a first cellular blood species from the plasma conveyed from the source, a second filtration media coupled to the tubing in series with the first filtration media to separate a second cellular blood species different than the first cellular blood species from the plasma conveyed from the source, to thereby produce a filtered plasma that is essentially free of the first and second cellular blood species, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, a photoactive material comprising methylene blue to be mixed with the cellular matter-reduced plasma to bind to an extracellular viral agent in the plasma and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum, and an overwrap enveloping the transfer container, the overwrap being made of a light filtering material including phthalocyanine pigments to absorb the light energy, the overwrap also including a vapor barrier material.
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47. A system for treating plasma the system comprising
a source container holding plasma that has been centrifugally separated from whole blood and is essentially free of red blood cells, the plasma containing leukocytes, platelets, and an extracellular viral agent, tubing coupled to the source container, a first filtration media coupled to the tubing to separate leukocytes from the plasma conveyed from the source container, a second filtration media coupled to the tubing downstream of the first filtration media to separate leukocytes and platelets from the plasma conveyed from the source, to thereby produce a filtered plasma that is essential free of red blood cells, the leukocytes, and platelets, a transfer container coupled to the tubing to receive the filtered plasma from the first and second filtration media, and a photoactive material to be mixed with the filtered plasma to bind to the extracellular viral agent and inactivate the extracellular viral agent upon exposure to light energy in a particular spectrum.
Specification