Plasma surface treatment of silicone hydrogel contact lenses

• US 6,193,369 B1
• Filed: 04/21/1999
• Issued: 02/27/2001
• Est. Priority Date: 05/05/1998
• Status: Expired due to Fees

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Grobe, George L., Moorehead, Michael J., Valint, Paul L. Jr., Ammon, Daniel M. Jr.
• Primary Examiner(s): Sugarman, Scott J.
• Application Number:
  US09/295,675
• Time in Patent Office: 678 Days
• Field of Search: 351/160.R, 351/160.H, 351/161, 351/162, 351/177
• US Class Current: 351/160.00H
• CPC Class Codes: B29D 11/00192 Demoulding, e.g. separating lenses from mould halves
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: C08J 2343/04 Homopolymers or copolymers of monomers containing silicon
• CPC Class Codes: C08J 2383/04 Polysiloxanes
• CPC Class Codes: C08J 7/123 Treatment by wave energy or particle radiation C08J7/18 takes precedence
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

The present invention provides an optically clear, hydrophilic coating upon the surface of a silicone hydrogel lens by subjecting the surface of the lens to a process comprising plasma treatment, hydration, and heat sterilization that is controlled to result in a silicate-containing film having a mosaic pattern of projecting plates surrounded by fissures when viewing a 50×50 micron square AFM image, wherein the peak-to-valley distances of the fissures are on average between about 100 and 500 angströms and the plate coverage is on average between about 40% to 99%.

Claims

1. A silicone hydrogel contact lens including a hydrophilic surface having a silicate-containing surface coating characterized by a mosaic pattern of projecting plates surrounded by receding fissures when viewing a 50×

50 micron square AFM image, wherein, as a result of a controlled manufacturing process, the average fissure depth is on average between about 100 and 500 angströ

ms and the plate coverage is on average between about 40 and 99 percent.

2. The contact lens of claim 1, wherein the fissure depth is on average between 150 and 200 angströ

ms.

3. The contact lens of claim 1, wherein the plate coverage is on average between about 60 and 99 percent.

4. The contact lens of claim 1, wherein the silicone hydrogel comprises 30 to 60 percent by weight of one or more silicone macromonomers, 1 to 35 percent by weight of one or more polysiloxanylalkyl (meth)acrylic monomers, and 20 to 40 percent by weight of a hydrophilic monomer.

5. The contact lens of claim 1, wherein the silane macromonomer is a poly(organosiloxane) capped with an unsaturated group at two or more ends.

6. The contact lens of claim 1 wherein the silane macromonomer is a silicon-containing vinyl carbonate or vinyl carbamate or a polyurethane-polysiloxane having one or more hard-soft-hard blocks and end-capped with a hydrophilic monomer.

7. The contact lens of claim 1, wherein the polysiloxanylalkyl (meth)acrylic monomers is methacryloxypropyl tris(trimethyl-siloxy)silane.

8. The contact lens of claim 1, wherein the hydrophilic monomer is selected from the group consisting of unsaturated carboxylic acids, acrylic substituted alcohols, vinyl lactams, acrylamides, vinyl carbonate or vinyl carbamate, oxazolone monomers, and mixtures thereof.

9. The contact lens of claim 1, wherein the hydrophilic monomer is selected from the group consisting of methacrylic and acrylic acids, 2-hydroxyethylmethacrylate and 2-hydroxyethylacrylate, N-vinyl pyrrolidone, methacrylamide, N,N-dimethylacrylamide, and mixtures thereof.