Medical ultrasonic diagnostic imaging method and apparatus

• US 6,193,659 B1
• Filed: 03/31/1999
• Issued: 02/27/2001
• Est. Priority Date: 07/15/1997
• Status: Expired due to Term

• Current Assignee: Siemens Medical Solutions USA Incorporated (Siemens AG)
• Original Assignee: Acuson Corporation (Siemens AG)
• Inventors: Sawatari, Ken, Bradley, Charles, Dodd, Stirling S., Ramamurthy, Bhaskar S., Zhao, Danhua, Maslak, Samuel H., Carp, Stuart L., Hedberg, David J., Need, Daniel E.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Imam, Ali M.
• Application Number:
  US09/282,397
• Time in Patent Office: 699 Days
• Field of Search: 600/437, 600/443, 600/447, 600/455-458, 367/7, 367/11, 367/138, 736/25
• US Class Current: 600/443
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: G01S 15/8915 using a transducer array
• CPC Class Codes: G01S 15/8927 using simultaneously or sequentially two or more subarrays or subapertures
• CPC Class Codes: G01S 15/895 characterised by the transmitted frequency spectrum
• CPC Class Codes: G01S 7/5202 for pulse systems
• CPC Class Codes: G01S 7/52038 involving non-linear properties of the propagation medium or of the reflective target

Abstract

An improvement to the method for harmonic imaging including the steps of (a) transmitting ultrasonic energy at a fundamental frequency and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency is provided. The transmitting step includes the step of: applying the plurality of waveforms to a respective plurality of transducer elements, a first waveform of the plurality of waveforms characterized by a first value of a harmonic power ratio, waveforms transmitted from the transducer elements and corresponding to the plurality of waveforms summing as an acoustic waveform substantially at the point, the acoustic waveform characterized by a second value of the harmonic power ratio less than the first value. The imaging method can also include a step for subdividing the transmit aperture into two or more subapertures, each subaperture having at least four adjacent transducer elements. The subapertures are phased differently with respect to one another to selectively reduce either fundamental components or harmonic components of echoes from tissue. These techniques can be used to improve contrast agent harmonic imaging as well as tissue harmonic imaging, depending upon the phase shift selected.

Claims

1. In a method comprising the steps of (a) transmitting a plurality of waveforms from a transducer at a fundamental frequency focused at a point and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency, an improvement wherein step (a) comprises the steps of:

(a1) applying said plurality of waveforms to a respective plurality of transducer elements, a first uni-polar waveform of said plurality of waveforms characterized by uniform amplitude and by a first value of a harmonic power ratio, waveforms transmitted from said transducer elements and corresponding to said plurality of waveforms summing as an acoustic waveform substantially at the point, said acoustic waveform characterized by a second value of said harmonic power ratio less than said first value.

2. The method of claim 1 wherein the step (a1) comprises (a2) generating said first waveform as a uniform amplitude signal comprising a first duration and (a3) generating a second waveform of said plurality of waveforms as a uniform amplitude signal comprising a second duration shorter than said first duration, respectively.

3. The method of claim 2 wherein the step (a2) comprises setting a first amplitude of said first waveform different than a second amplitude of said second waveform by a shape amplitude.

4. The method of claim 1 wherein the step (a) further comprises (a2) filtering said plurality of waveforms.

5. The method of claim 1 wherein the step (a1) comprises applying at least a second waveform of said plurality of waveforms to one of said plurality of transducer elements, said second waveform characterized by a third value of said harmonic power ratio greater than said second value of said harmonic power ratio.

6. The method of claim 1 wherein step (a1) comprises delaying said first waveform relative to a second waveform of said plurality of waveforms by a shape delay.

7. The method of claim 6 wherein the step (a1) comprises delaying said first waveform by an integer number of cycles relative to said second waveform, wherein said acoustic waveform comprises a gradually increasing and gradually decreasing shape.

8. The method of claim 6 wherein the step (a1) comprises delaying said first waveform by a fraction of a cycle relative to said second waveform.

9. The method of claim 1 wherein the step (a1l) comprises generating said first waveform comprising a first number of cycles and a second waveform of said plurality of waveforms comprising a second number of cycles less than said first number of cycles.

10. The method of claim 9 wherein the step (a1) comprises setting said second number as an integer value at least two less than said first number.

11. The method of claim 10 wherein the step (a1l) comprises delaying said second waveform relative to said first waveform by a shape delay comprising a third number of cycles, said third number of cycles substantially half the difference between said first and second numbers, wherein said acoustic waveform comprises a gradually increasing and gradually decreasing shape.

12. The method of claim 1 wherein the step (a1) comprises setting characteristics selected from the group of:

(i) a shape delay;

(ii) a number of cycles;

(iii) a shape amplitude; and

(iv) any combination thereof.

13. The method of claim 1 wherein said first waveform and a second waveform of said plurality of waveforms comprise substantially rectangular waveforms characterized by uniform amplitude.

14. The method of claim 1 further comprising the step of providing a contrast agent.

15. The method of claim 1 wherein the step (a1) comprises applying said first waveform to a first group of said transducer elements and transmitting a second waveform of said plurality of waveforms from a second group of said transducer elements.

16. The method of claim 15 wherein the step (a1) comprises applying to said first group comprising a center group of transducer elements.

17. The method of claim 15 wherein the step (a1) comprises applying to said first and second groups comprising alternating transducer elements.

18. The method of claim 1 further comprising the steps of:

(a2) transmitting at least said first waveform, and a second and a third waveform of said plurality of waveforms from at least said first, a second and a third transducer element, respectively, said third waveform characterized by a third value of said harmonic power ratio greater than said second value and relative to at least said first and second waveforms as a function of a shape comprising a sum of said first, second and third waveforms and rising gradually to a respective maximum value and falling gradually from said respective maximum value, said acoustic waveform comprising said shape.

19. The method of claim 1 further comprising the step of (a2) modulating a pulse width of pulses within said first waveform.

20. The method of claim 1 further comprising the step of shaping the amplitude of said first waveform.

21. The method of claim 1 further comprising the step or steps of any combination of two or three of steps a2 and a3:

(a2) modulating a pulse width of at least said first waveform;

(a3) shaping the amplitude of said first waveform.

22. The method of claim 1 wherein step (a) further comprises:

starting transmission for at least three waveforms of the plurality of waveforms as a function of at least three different delays in addition to focusing delays; and

wherein the acoustic waveform is associated with reduced energy at the harmonic of the fundamental frequency, a characteristic of said reduction responsive to the three different delays.

23. The method of claim 1 wherein step (a) further comprises:

transmitting from two groupings of elements the plurality of waveforms, the two groupings selected from groupings consisting of;

unequal groupings, groupings comprising at least two adjacent transducer elements and combinations thereof, the waveforms of the plurality of waveforms associated with a first one of the groupings of elements responsive to different delays than the waveforms of the plurality of waveforms associated with a second one of the groupings of elements, a characteristic of said reduction responsive to the grouping of elements.

24. The method of claim 23 wherein step (a) further comprises:

transmitting from the first grouping with delays in addition to focusing delays and from the second grouping with focusing delays.

25. The method of claim 24 wherein step (a) comprises:

transmitting from the first grouping, the first grouping comprising elements non-symmetrical about a center element.

26. An apparatus for transmitting ultrasonic energy at a fundamental frequency focused substantially at a point for receipt of reflected ultrasonic energy at a harmonic of the fundamental frequency comprising:

a transducer comprising a plurality of transducer elements;

a beamformer for applying a plurality of waveforms to said plurality of transducer elements respectively, a first uni-polar waveform of said plurality of waveforms characterized by a uniform amplitude and a first value of a harmonic power ratio, waveforms transmitted from said transducer elements and corresponding to said plurality of waveforms summing as an acoustic waveform substantially at the point, said acoustic waveform characterized by a second value of said harmonic power ratio less than said first value.

27. A method of generating waveforms in the acoustic domain for harmonic imaging comprising the steps of:

transmitting at a first start time at least a first waveform comprising a first number of cycles;

transmitting at a second start time at least a second waveform comprising said first number of cycles, wherein said second start time corresponds to at least a one cycle delay in addition to a focusing delay from said first start time;

said first and second waveforms acoustically summing to contribute to a third waveform at a point, said third waveform comprising a shape rising gradually to a respective value and falling gradually from said respective value.

28. A method of generating waveforms in the acoustic domain for harmonic imaging comprising the steps of:

transmitting at a first start time at least a first waveform comprising a first number of cycles;

transmitting at a second start time at least a second waveform comprising a second number of cycles, wherein said second number of cycles comprises at least two cycles less than said first number and said second start time corresponds to at least a one cycle delay in addition to a focusing delay from said first start time;

said first and second waveforms acoustically summing to contribute to a third waveform at a point, said third waveform comprising a shape rising gradually to a respective value and falling gradually from said respective value.

29. A method of generating waveforms in the acoustic domain for harmonic imaging comprising the steps of:

transmitting at least a first waveform comprising a first amplitude;

transmitting at least a second waveform comprising a second amplitude selected relative to the first amplitude in addition to an apodization amplitude;

said first and second waveforms acoustically summing to contribute to a third waveform at a point, said third waveform comprising a shape rising gradually to a respective value and falling gradually from said respective value and characterized by a number of amplitude levels greater than a number of amplitude levels associated with the first and second waveforms.

30. In a method comprising the steps of (a) transmitting a plurality of waveforms from a transducer at a fundamental frequency focused at a point and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency, an improvement wherein step (a) comprises the steps of:

(a1) starting transmission for at least three waveforms of the plurality of waveforms as a function of at least three different delays in addition to focusing delays;

said at least three waveforms acoustically summing as an acoustic waveform, the acoustic waveform associated with reduced energy at the harmonic of the fundamental frequency, the position of the reduction responsive to the three different delays.

31. The method of claim 30 wherein step (a) further comprises transmitting from two groupings of elements for waveforms associated with respective ones of at least two of the at least three different delays, the two groupings selected from groupings consisting of:

unequal groupings, groupings comprising at least two adjacent transducer elements and combinations thereof, a characteristic of said reduction responsive to the grouping of elements.

32. The method of claim 31 wherein step (a) comprises:

transmitting the waveforms associated with the three different delays from a first portion of an active aperture and transmitting waveforms associated with focusing delays from a second portion of the active aperture.

33. In a method comprising the steps of (a) transmitting a plurality of waveforms from a transducer at a fundamental frequency focused at a point and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency, an improvement wherein step (a) comprises the steps of:

(a1) transmitting from two groupings of elements waveforms associated with respective ones of at least two different delays, the two groupings selected from groupings consisting of;

unequal groupings, grouping comprising at least two adjacent transducer elements and combinations thereof;

said waveforms acoustically summing as an acoustic waveform, the acoustic waveform associated with reduced energy at the harmonic of the fundamental frequency, a characteristic of said reduction responsive to the grouping of elements.

34. The method of claim 33 wherein step (a) further comprises:

starting transmission for at least three waveforms of the plurality of waveforms as a function of at least three different delays in addition to focusing delays;

said at least three waveforms acoustically summing as the acoustic waveform, the position of the reduction responsive to the three different delays.

35. The method of claim 33 wherein step (a) comprises:

transmitting from unequal groupings.

36. The method of claim 33 wherein step (a) comprises:

transmitting from groupings each comprising at least two adjacent transducer elements.

37. In a method comprising the steps of (a) transmitting a plurality of waveforms from a transducer at a fundamental frequency focused at a point in a target and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency during an imaging session, the target being free of contrast agent during the entire imaging session, an improvement wherein step (a) comprises the steps of:

(a1) applying said plurality of waveforms to a respective plurality of transducer elements during the imaging session, a first waveform of said plurality of waveforms characterized by a first value of a harmonic power ratio, waveforms transmitted from said transducer elements and corresponding to said plurality of waveforms summing as an acoustic waveform substantially at the point, said acoustic waveform characterized by a second value of said harmonic power ratio less than said first value.

38. The method of claim 37 wherein the step (a1) comprises (a2) generating said first waveform as a uniform amplitude signal comprising a first duration and (a3) generating a second waveform of said plurality of waveforms as a uniform amplitude signal comprising a second duration shorter than said first duration, respectively.

39. The method of claim 37 wherein the step (a) further comprises (a2) filtering said plurality of waveforms.

40. The method of claim 37 wherein the step (a1) comprises applying at least a second waveform of said plurality of waveforms to one of said plurality of transducer elements, said second waveform characterized by a third value of said harmonic power ratio greater than said second value of said harmonic power ratio.

41. The method of claim 37 wherein step (a1) comprises delaying said first waveform relative to a second waveform of said plurality of waveforms by a shape delay.

42. The method of claim 41 wherein the step (a1) comprises delaying said first waveform by an integer number of cycles relative to said second waveform, wherein said acoustic waveform comprises a gradually increasing and gradually decreasing shape.

43. The method of claim 41 wherein the step (a1) comprises delaying said first waveform by a fraction of a cycle relative to said second waveform.

44. The method of claim 37 wherein the step (a1l) comprises generating said first waveform comprising a first number of cycles and a second waveform of said plurality of waveforms comprising a second number of cycles less than said first number of cycles.

45. The method of claim 44 wherein the step (a1) comprises setting said second number as an integer value at least two less than said first number.

46. The method of claim 45 wherein the step (a1) comprises delaying said second waveform relative to said first waveform by a shape delay comprising a third number of cycles, said third number of cycles substantially half the difference between said first and second numbers, wherein said acoustic waveform comprises a gradually increasing and gradually decreasing shape.

47. The method of claim 37 wherein the step (a2) comprises setting a first amplitude of said first waveform different than a second amplitude of said second waveform by a shape amplitude.

48. The method of claim 37 wherein the step (a1) comprises setting characteristics selected from the group of:

(i) a shape delay;

(ii) a number of cycles;

(iii) a shape amplitude; and

(iv) any combination thereof.

49. The method of claim 37 wherein at least said first waveform and a second waveform of said plurality of waveforms comprise uni-polar waveforms characterized by uniform amplitude.

50. The method of claim 37 wherein at least said first waveform and a second waveform of said plurality of waveforms comprise bi-polar waveforms characterized by uniform amplitude.

51. The method of claim 37 wherein said first waveform and a second waveform of said plurality of waveforms comprise substantially rectangular waveforms characterized by uniform amplitude.

52. The method of claim 37 wherein said first waveform and a second waveform of said plurality of waveforms comprise sinusoidal waveforms characterized by uniform amplitude.

53. The method of claim 37 wherein the step (al) comprises applying said first waveform to a first group of said transducer elements and transmitting a second waveform of said plurality of waveforms from a second group of said transducer elements.

54. The method of claim 53 wherein the step (a1) comprises applying to said first group comprising a center group of transducer elements.

55. The method of claim 53 wherein the step (a1) comprises applying to said first and second groups comprising alternating transducer elements.

56. The method of claim 37 further comprising the steps of:

(a2) transmitting at least said first waveform, and a second and a third waveform of said plurality of waveforms from at least said first, a second and a third transducer element, respectively, said third waveform characterized by a third value of said harmonic power ratio greater than said second value and relative to at least said first and second waveforms as a function of a shape comprising a sum of said first, second and third waveforms and rising gradually to a respective maximum value and falling gradually from said respective maximum value, said acoustic waveform comprising said shape.

57. The method of claim 37 further comprising the step of (a1) modulating a pulse width of pulses within said first waveform.

58. The method of claim 37 further comprising the step of shaping the amplitude of said first waveform.

59. The method of claim 37 further comprising the step or steps of any combination of two or three of steps a2 and a3:

(a2) modulating a pulse width of at least said first waveform;

(a3) shaping the amplitude of said first waveform.

60. The method of claim 37 wherein step (a) further comprises:

starting transmission for at least three waveforms of the plurality of waveforms as a function of at least three different delays in addition to focusing delays;

the acoustic waveform associated with reduced energy at the harmonic of the fundamental frequency, a characteristic of said reduction responsive the three different delays.

61. The method of claim 37 wherein step (a) further comprises:

transmitting from two groupings of elements the plurality of waveforms, the two groupings selected from groupings consisting of;

unequal groupings, groupings comprising at least two adjacent transducer elements and combinations thereof, the waveforms of the plurality of waveforms associated with one of the groupings of elements responsive to different delays than the waveforms of the plurality of waveforms associated with a second one of the groupings of elements, a characteristic of said reduction responsive to the grouping of elements.

62. The method of claim 61 wherein step (a) further comprises:

transmitting from the first grouping with delays in addition to focusing delays and from the second grouping with focusing delays.

63. The method of claim 62 wherein step (a) comprises:

transmitting from the first grouping, the first grouping comprising elements non-symmetrical about a center element.

64. In a method comprising the steps of (a) transmitting a plurality of waveforms from a transducer at a fundamental frequency into a target for each of a plurality of scan lines and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency response to step (a), an improvement wherein step (a) comprises the steps of:

(a1) changing an aperture for transmitting waveforms with different delays in addition to focusing delays as a function of an angle of one of said plurality of scan lines.

65. The method of claim 64 wherein step (a1) comprises changing the aperture to at least three different sizes for at least three respective groups of said plurality of scan lines, the three groups comprising a center group, an intermediate group and an edge group.

66. The method of claim 64 wherein step (a1) comprises changing the aperture from a full aperture to no aperture.

67. The method of claim 66 wherein step (a1) comprises decreasing the aperture as a function of the angle away from a center scan line of said plurality of scan lines.

68. The method of claim 64 wherein step (a) comprises:

(a2) changing another aperture for transmitting waveforms with focusing delays as a function of the aperture of step (a1).

69. The method of claim 68 wherein step (a) comprises:

placing the aperture of step (a1) off-set from a center of an active aperture.

70. In a method comprising the steps of (a) transmitting a plurality of waveforms from a transducer at a fundamental frequency into a target for each of a plurality of scan lines and (b) receiving reflected ultrasonic energy at a harmonic of the fundamental frequency response to step (a), an improvement wherein step (a) comprises the steps of:

(a1) changing an aperture for transmitting waveforms with different phases in addition to focusing delays as a function of an angle of one of said plurality of scan lines.

71. The method of claim 70 wherein step (a1l) comprises changing the aperture to at least three different sizes for at least three respective groups of said plurality of scan lines, the three groups comprising a center group, an intermediate group and an edge group.

72. The method of claim 70 wherein step (a1) comprises changing the aperture from a full aperture to no aperture.

73. The method of claim 72 wherein step (a1) comprises decreasing the aperture as a function of the angle away from a center scan line of said plurality of scan lines.