Endoprosthesis that can be percutaneously implanted in the patient's body

• US 6,193,746 B1
• Filed: 09/04/1996
• Issued: 02/27/2001
• Est. Priority Date: 07/08/1992
• Status: Expired due to Term

• Current Assignee: Ernst Peter Strecker
• Original Assignee: Ernst Peter Strecker
• Inventors: Strecker, Ernst Peter
• Primary Examiner(s): Willse, David H.
• Application Number:
  US08/707,820
• Time in Patent Office: 1,637 Days
• Field of Search: 673/1, 673/12, 606/191-195, 606/198, 623/1.38, 623/1.39, 623/1.4, 623/1.42, 623/1.43, 623/1.13, 623/1.14
• US Class Current: 623/1.13
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

An endoprosthesis in the form of an elongated hollow structure that can be implanted percutaneously with a catheter in a blood vessel or other cavity of the body and once correctly positioned will expand from an initial state with a narrow lumen into a state with a lumen that is as wide as its placement will allow. It has a lining of a wrapping material that deforms plastically without fissuring as it expands from the state with the narrow lumen to the state with the wide lumen. Another embodiment is a stent with a wrinkled lining that smoothes out as the stent expands. The lining is impregnated with at least one medication that will gradually and preferably at a uniform rate be released to the patient once the prosthesis is in place.

Claims

1. An endoprosthesis comprising:

an elongated hollow structure, said structure being deliverable into a body lumen for dwelling therein, said structure being expandable and having an initial state of decreased outer diameter during delivery relative to the outer diameter of said structure during dwelling, said elongated hollow structure having a continuous circumferential support along its entire length, and

a lining impregnated with medication for delivery to a wall of said body lumen, said lining being continuous and connected along said structure and expandable therewith, said lining deforming plastically under pressure associated with expansion of the hollow structure, such that the lining does not crack during expansion.

2. The endoprosthesis of claim 1, wherein said lining is associated with a surface of said structure.

3. The endoprosthesis of claim 1, wherein said medication is dissolved in said lining material.

4. The endoprosthesis of claim 1, wherein said medication is encapsulated in beads impregnated in said lining material.

5. The endoprosthesis of claim 1, wherein said lining is biodegradable.

6. The endoprosthesis of claim 1, wherein said lining comprises pores.

7. The endoprosthesis of claim 6, wherein said pores are no larger than 0.5 μ

m in diameter.

8. The endoprosthesis of claim 6 in which the lining comprises pores which are too small to pass smooth muscle cells.

9. The endoprosthesis of claim 6 in which the pores increase in size as the structure and lining expand, whereby drug release occurs at a greater rate as the structure expands.

10. The endoprosthesis of claim 1, wherein said lining comprises more than one layer.

11. The endoprosthesis of claim 10, wherein each of said layers is impregnated with a different medication.

12. The endoprosthesis of claim 11, wherein each of said layers is formed of a material that biodegrades at a different rate from the material of other layers.

13. The endoprosthesis of claim 12, wherein an inner layer of said liner biodegrades more rapidly than an outer layer.

14. The endoprosthesis of claim 10, wherein said endoprosthesis comprises an outer layer comprising pores which widen during expansion, said medication being released upon expansion of said outer layer.

15. The endoprosthesis of claim 10, wherein said endoprosthesis comprises an inner layer comprising pores which widen during expansion, said medication being released upon expansion of said inner layer.

16. The endoprosthesis of claim 1, wherein said structure is in the form of a mesh of interconnected open loops forming apertures, said mesh comprising a lateral hole to allow unimpeded blood supply to a branching vessel of an artery accommodating said endoprosthesis.

17. The endoprosthesis of claim 16, wherein said lining encloses said mesh covering said apertures, excluding said lateral hole.

18. The endoprosthesis of claim 16, wherein said lining encloses said mesh without covering said apertures.

19. The endoprosthesis of claim 1, further comprising a detachable medicating tube associated with said lining.

20. The endoprosthesis of claim 1 in which,

the lining comprises a membrane having an inner wall and an outer wall, and a space between the walls, the outer wall comprising pores for drug release; and

the endoprosthesis further comprising a detachable medicating tube which is connected to the space.

21. The method of claim 1 in which the medication comprises an antithrombotic, an antiproliferative, a cytostatic material, an anti-arteriosclerotic, or genetic material.

22. An endoprosthesis comprising:

an elongated hollow structure, said structure being deliverable into a body lumen for dwelling therein, said structure being expandable and having an initial state of decreased outer diameter during delivery relative to the outer diameter of said structure during dwelling, said elongated hollow structure having a continuous circumferential support along its entire length, and

a lining impregnated with an antithrombotic medication for delivery to a wall of said body lumen, said lining being continuous and connected along said structure and expandable therewith, said lining deforming plastically under pressure associated with expansion of the hollow structure, such that the lining does not crack during expansion.

23. An endoprosthesis comprising:

an elongated hollow structure, said structure being deliverable into a body lumen for dwelling therein, said structure being expandable and having an initial state of decreased outer diameter during delivery relative to the outer diameter of said structure during dwelling, said elongated hollow structure having a continuous circumferential support along its entire length, and

a lining impregnated with an antiproliferative medication for delivery to a wall of said body lumen, said lining being continuous and connected along said structure and expandable therewith, said lining deforming plastically under pressure associated with expansion of the hollow structure, such that the lining does not crack during expansion.

24. An endoprosthesis comprising:

an elongated hollow structure, said structure being deliverable into a body lumen for dwelling therein, said structure being expandable and having an initial state of decreased outer diameter during delivery relative to the outer diameter of said structure during dwelling, said elongated hollow structure having a continuous circumferential support along its entire length, and

a lining impregnated with a cytostatic medication for delivery to a wall of said body lumen, said lining being continuous and connected along said structure and expandable therewith, said lining deforming plastically under pressure associated with expansion of the hollow structure, such that the lining does not crack during expansion.

25. An endoprosthesis comprising:

an elongated hollow structure, said structure being deliverable into a body lumen for dwelling therein, said structure being expandable and having an initial state of decreased outer diameter during delivery relative to the outer diameter of said structure during dwelling, said elongated hollow structure having a continuous circumferential support along its entire length, and

a lining impregnated with an anti-arteriosclerotic medication for delivery to a wall of said body lumen, said lining being continuous and connected along said structure and expandable therewith, said lining deforming plastically under pressure associated with expansion of the hollow structure, such that the lining does not crack during expansion.

26. An endoprosthesis comprising:

an elongated hollow structure, said structure being deliverable into a body lumen for dwelling therein, said structure being expandable and having an initial state of decreased outer diameter during delivery relative to the outer diameter of said structure during dwelling, said elongated hollow structure having a continuous circumferential support along its entire length, and

a lining impregnated with a genetic material for delivery to a wall of said body lumen, said lining being continuous and connected along said structure and expandable therewith, said lining deforming plastically under pressure associated with expansion of the hollow structure, such that the lining does not crack during expansion.

27. An endoprosthesis comprising:

an elongated hollow structure, said structure being deliverable into a body lumen for dwelling therein, said structure being expandable and having an initial state of decreased outer diameter during delivery relative to the outer diameter of said structure during dwelling; and

a lining impregnated with a drug for delivery to a wall of said body lumen, said lining being continuous and connected along said structure and expandable therewith, said lining deforming plastically under pressure associated with expansion of the hollow structure, such that the lining does not crack during expansion.