Calcification-resistant biomaterials
First Claim
1. A bioprosthetic article comprising a biocompatible material and an exogenous storage structure that is bound to the biocompatible material, said storage structure comprising a metal binding protein and said storage structure having a quantity of calcification inhibitors releasably bound thereto.
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Abstract
In general, the invention features a bioprosthetic article including a biocompatible material having at least one bound exogenous storage structure, the storage structure having a quantity of calcification inhibitors releasably bound thereto. The storage structure can be a protein or a synthetic polymer. The calcification inhibitors include metal ions and phosphatase inhibitors generally. Bifunctional metal chelators can be bound to endogenous proteins to deliver metal ions.
65 Citations
20 Claims
- 1. A bioprosthetic article comprising a biocompatible material and an exogenous storage structure that is bound to the biocompatible material, said storage structure comprising a metal binding protein and said storage structure having a quantity of calcification inhibitors releasably bound thereto.
- 14. A bioprosthetic article comprising a biocompatible material and an exogenous, attached protein with bound bifunctional chelators and with a quantity of multivalent metal cations releasably bound to the bifunctional chelators.
- 15. A bioprosthetic article comprising a biocompatible material and an exogenous metal binding protein that is bound to the biocompatible material, said protein having a quantity of calcification inhibitors bound thereto, wherein said protein has been modified to create metal binding capability.
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17. A bioprosthetic article comprising a biocompatible material and an exogenous, macromolecular storage structure that is bound to the biocompatible material, said storage structure having a quantity of calcification inhibiting multivalent metal cations releasably bound thereto, wherein the storage structure comprises a synthetic organometallic polymer.
Specification