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DNA sequencing by mass spectrometry

  • US 6,194,144 B1
  • Filed: 03/18/1996
  • Issued: 02/27/2001
  • Est. Priority Date: 01/07/1993
  • Status: Expired due to Term
First Claim
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1. A method for determining the sequence of a nucleic acid, comprising the steps of:

  • a) generating at least two base-specifically terminated nucleic acid fragments containing deazapurine nucleotides;

    b) determining the molecular weight value of each base-specifically terminated fragment by mass spectrometry, wherein the molecular weight values of at least two base-specifically terminated fragments are determined concurrently; and

    c) determining the sequence of the nucleic acid by aligning the base-specifically terminated nucleic acid fragments according to molecular weight.

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