Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
First Claim
1. A method of protecting the optic nerve and retina of a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on said nerve cells an effective amount of a compound of formula I to inhibit or prevent nerve cell injury or death wherein the 2-imidazolin-2-ylamino group is in either the 5- or 6-position of the quinoxaline nucleus;
- x, y and z are in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and
R is an optional substituent in either the 2- or 3-position of the quinoxaline nucleus and may be hydrogen, lower alkyl or lower alkoxy, or pharmaceutically acceptable salts thereof and mixtures thereof, wherein said noxious action is selected from the group consisting of glaucomatous optic neuropathy, atrophy associated with dry ARMD, laser light directed into the eye in a procedure for treatment of wet ARMD, ischemia secondary to glaucoma and photoreceptor cell damage associated with retinitis pigmentosa.
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Accused Products
Abstract
The present invention provides a method of protecting the optic or retinal nerve cells of a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on said nerve cells an effective amount of a compound of formula I to inhibit or prevent nerve cell injury or death
wherein the 2-imidazolin-2-ylamino group is in either the 5- or 6-position of the quinoxaline nucleus; x, y and z are in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and R is an optional substituent in either the 2- or 3-position of the quinoxaline nucleus and may be hydrogen, lower alkyl or lower alkoxy, or pharmaceutically acceptable salts thereof and mixtures thereof. Such noxious action may result from glaucomatous optic neuropathy, age related macular degeneration or retinitis pigmentosa.
144 Citations
6 Claims
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1. A method of protecting the optic nerve and retina of a mammal comprising administering to said mammal suffering from or at risk of suffering a noxious action on said nerve cells an effective amount of a compound of formula I to inhibit or prevent nerve cell injury or death
wherein the 2-imidazolin-2-ylamino group is in either the 5- or 6-position of the quinoxaline nucleus; - x, y and z are in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and
R is an optional substituent in either the 2- or 3-position of the quinoxaline nucleus and may be hydrogen, lower alkyl or lower alkoxy, or pharmaceutically acceptable salts thereof and mixtures thereof, wherein said noxious action is selected from the group consisting of glaucomatous optic neuropathy, atrophy associated with dry ARMD, laser light directed into the eye in a procedure for treatment of wet ARMD, ischemia secondary to glaucoma and photoreceptor cell damage associated with retinitis pigmentosa. - View Dependent Claims (2, 3, 4, 5, 6)
- x, y and z are in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and
Specification
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- Resources
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Current AssigneeAllergan, Inc. (Canada) (Abbvie Incorporated)
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Original AssigneeAllergan Sales LLC (Abbvie Incorporated)
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InventorsWheeler, Larry A., Woldemussie, Elizabeth, Lai, Ronald K.
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Primary Examiner(s)FAY, ZOHREH A
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Application NumberUS09/225,036Time in Patent Office785 DaysField of Search514/252.01, 514/912, 514/913US Class Current514/250CPC Class CodesA61K 31/495 having six-membered rings w...A61K 31/498 Pyrazines or piperazines or...A61P 27/02 Ophthalmic agentsA61P 27/06 Antiglaucoma agents or mioticsA61P 43/00 Drugs for specific purposes...
