Method of making a glass array plate with closure

• US 6,196,026 B1
• Filed: 03/01/1999
• Issued: 03/06/2001
• Est. Priority Date: 03/18/1998
• Status: Expired due to Term

• Current Assignee: Corning Incorporated
• Original Assignee: Corning Incorporated
• Inventors: Anderson, James G., Dannoux, Thierry L. A.
• Primary Examiner(s): VINCENT, SEAN E
• Application Number:
  US09/259,734
• Time in Patent Office: 736 Days
• Field of Search: 65/44, 65/45, 65/47, 65/65, 65/67, 65/97
• US Class Current: 65/44
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: B01L 3/50853 with covers or lids
• CPC Class Codes: C03B 13/14 Rolling other articles , i.e. not covered by C03B13/01 - C03B13/12, e.g. channeled articles, briquette-shaped articles
• CPC Class Codes: C03B 17/02 Forming molten glass coated with coloured layers; Forming molten glass of different compositions or layers; Forming molten glass comprising reinforcements or inserts
• CPC Class Codes: C03B 23/203 Uniting glass sheets C03B23/24 takes precedence
• CPC Class Codes: C03B 23/24 Making hollow glass sheets or bricks
• CPC Class Codes: C03B 23/26 Punching reheated glass
• CPC Class Codes: Y10T 428/1317 Multilayer [continuous layer]

Abstract

A method of making a glass multiwell plate for use in biological or chemical laboratory applications whereby the plate is formed by a single ribbon of molten glass passing twice over a mold such that the first section of glass takes the form of the mold and thereby forms the wells of the plate while the second section of glass covers the wells and forms a top surface of the plate. Holes are cut through the top surface, above each well to enable access.

Claims

1. A method of making a multiwell plate made substantially of glass comprising the steps of:

(a) delivering and depositing a first or well-forming ribbon of molten glass to a surface of a mold assembly having a mold cavity possessing at least one well forming depression formed therewithin and a peripheral surface, wherein the well forming ribbon overlies the mold cavity and the peripheral surface of the mold assembly;

(b) causing the well-forming ribbon of molten glass to substantially conform to the contour of the mold cavity resulting in the formation of at least one well in the ribbon of molten glass;

(c) delivering and depositing a second or sealing ribbon of molten glass to the outer surface of the well forming ribbon of molten glass wherein the viscosity of the sealing ribbon is such that the sealing ribbon (1) bridges but does not sag into complete contact with the surface of the at least one well of the well forming ribbon and (2) forms a hermetic seal wherever the sealing ribbon contacts the well-forming ribbon; and

,

(d) removing the glass article from the mold; and

(e) puncturing a hole through the sealing ribbon and over an approximate center of the at least one well thereby forming a series of self contained wells that may be accessed through the hole in the sealing ribbon.

2. The method of claim 1 including the additional step of applying a vacuum to the under surface of the channel forming ribbon of molten glass thereby causing the well forming ribbon to substantially conform to the contour of the mold cavity well forming depression.

3. The method of claim 1 wherein said puncturing step is performed by an array of gas flames.

4. The method of claim 3 wherein the puncturing step occurs while the sealing ribbon is still in a molten state.

5. The method of claim 3 wherein the puncturing step occurs after the piece is ejected from the mold.