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Methods and apparatus for optically imaging neuronal tissue and activity

DC
  • US 6,196,226 B1
  • Filed: 06/07/1995
  • Issued: 03/06/2001
  • Est. Priority Date: 08/10/1990
  • Status: Expired due to Fees
First Claim
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1. A physiologically non-invasive method for detecting optical changes indicative of neuronal activity or dysfunction in an area of interest in a human patient, comprising:

  • (a) illuminating the area of interest with an illumination source emitting electromagnetic radiation (emr) having at least one wavelength of from about 450 nm to about 2500 nm;

    (b) detecting one or more optical properties of the area of interest when it is illuminated with the emr using a photon detector and acquiring and storing a control data set representing the one or more optical properties detected;

    (c) detecting one or more properties of the area of interest at a time different from acquisition of the control data set and acquiring a subsequent data set representing the one or more optical properties detected during the different time; and

    (d) comparing the subsequent data set with the control data set to produce a comparison data set that identifies changes in the one or more optical properties and thereby identifies areas of neuronal activity or dysfunction.

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