Doppler ultrasound method and apparatus for monitoring blood flow

• US 6,196,972 B1
• Filed: 11/11/1998
• Issued: 03/06/2001
• Est. Priority Date: 11/11/1998
• Status: Expired due to Term

• Current Assignee: Spentech Incorporated
• Original Assignee: Spentech Incorporated
• Inventors: Moehring, Mark A.
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Imam, Ali M
• Application Number:
  US09/190,402
• Time in Patent Office: 846 Days
• Field of Search: 600/437, 600/440, 600/441, 600/454, 600/455, 736/26, 333/138, 342/457
• US Class Current: 600/454
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0816 using echo-encephalography
• CPC Class Codes: A61B 8/463 characterised by displaying multiple images or images and diagnostic data on one display composite display in devices for short-range imaging with acoustic waves G01S7/52074
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: G01S 15/8984 Measuring the velocity vector
• CPC Class Codes: G01S 15/8988 Colour Doppler imaging
• CPC Class Codes: G01S 7/52036 using analysis of echo signal for target characterisation
• CPC Class Codes: G01S 7/52046 Techniques for image enhancement involving transmitter or receiver image enhancement by image data processing G06T5/00
• CPC Class Codes: G01S 7/52071 Multicolour displays; using colour coding; Optimising colour or information content in displays, e.g. parametric imaging
• CPC Class Codes: G01S 7/52073 Production of cursor lines, markers or indicia by electronic means

Abstract

A pulse Doppler ultrasound system and associated methods are described for monitoring blood flow. A graphical information display includes simultaneously displayed depth-mode and spectrogram displays. The depth-mode display indicates the various positions along the ultrasound beam axis at which blood flow is detected. These positions are indicated as one or more colored regions, with the color indicating direction of blood flow and varying in intensity as a function of detected Doppler ultrasound signal amplitude or detected blood flow velocity. The depth-mode display also includes a pointer whose position may be selected by a user. The spectrogram displayed corresponds to the location identified by the pointer. Embolus detection and characterization are also provided.

Claims

1. A visual display device for providing information in connection with Doppler ultrasound monitoring of blood flow, comprising:

a display controller structured to control a first graphical display and a second graphical display, the first graphical display to indicate as a function of time a plurality of locations along an ultrasound beam axis at which blood flow is detected by varying intensity as a function of detected Doppler ultrasound signal amplitude at each of the locations, the second graphical display to indicate velocities of monitored blood flow at a selected location included in the first graphical display.

2. The user interface of claim 1 wherein the plurality of locations is a first plurality and wherein the graphical display indicates a second plurality of locations along the ultrasound beam axis at which blood flow is not detected.

3. The user interface of claim 1 wherein the first graphical display includes first and second colors associated with blood flow in first and second directions, respectively, the first and second colors having intensities varying as a function of detected Doppler ultrasound amplitude.

4. The user interface of claim 1 wherein the first graphical display includes a color region corresponding with the locations at which blood flow is detected.

5. The user interface of claim 1 wherein the first graphical display includes a color region corresponding with the locations at which blood flow is detected, the color having varying intensity as a function of a detected Doppler ultrasound signal amplitude.

6. The user interface of claim 1 wherein the first graphical display includes a color region corresponding with the locations at which blood flow is detected, the color associated with detected blood flow direction and having varying intensity as a function of a detected Doppler ultrasound signal amplitude.

7. The user interface of claim 1 wherein the first graphical display includes a color region corresponding with the locations at which blood flow is detected, the color associated with detected blood flow direction and having varying intensity as a function of detected blood flow velocities and detected Doppler ultrasound signal amplitude.

8. The user interface of claim 1 wherein the second graphical display is a spectrogram indicating the velocities of the monitored blood flow at the selected location as a function of time.

9. The user interface of claim 1 wherein the first and second graphical displays are provided simultaneously.

10. The user interface of claim 1 wherein the display controller further controls the first graphical display to display a location indicator identifying the selected location.

11. The user interface of claim 10 wherein the first graphical display includes a color region corresponding with the locations at which blood flow is detected, the location indicator being a pointer directed towards a position within the color region, and wherein the second graphical display is a spectrogram indicating the velocities of the monitored blood flow at the selected location as a function of time.

12. A graphical display for providing information in connection with Doppler ultrasound monitoring of blood flow, comprising:

a display controller to provide a blood locator display to depict as a function of time a plurality of locations along an ultrasound beam is at which blood flow is detected by varying intensity as a function of detected Doppler ultrasound amplitude at each of the locations, and to further provide a spectrogram to depict detected blood flow velocities as a function of time at a selected one of the plurality of locations.

13. The graphical display of claim 12 wherein the display controller further provides a location indicator identifying the selected location.

14. The graphical display of claim 13 wherein the location indicator is a pointer directed to the selected location depicted in the blood locator display.

15. The graphical display of claim 12 wherein the blood locator display includes a color region corresponding to the depicted locations at which blood flow is detected, the color having varying intensity as a function of a detected Doppler ultrasound signal amplitude.

16. The graphical display of claim 12 wherein the blood locator display includes a color region corresponding to the depicted locations at which blood flow is detected, the color associated with blood flow direction and having varying intensity as a function of a detected Doppler ultrasound signal amplitude.

17. The graphical display of claim 12 wherein the blood locator display includes a color region corresponding to the depicted locations at which blood flow is detected, the color associated with blood flow direction and having varying intensity as a function of a detected blood flow velocities and detected Doppler ultrasound amplitude.

18. The graphical display of claim 12 wherein the blood locator display and the spectrogram are displayed simultaneously.

19. The graphical display of claim 12 wherein the plurality of locations is a first plurality and wherein the graphical display indicates a second plurality of locations along the ultrasound beam axis at which blood flow is not detected.

20. A graphical display for a Doppler ultrasound system to provide information in connection with Doppler ultrasound monitoring of blood flow, comprising:

a display controller;

a blood locator display coupled to the display controller and having a color region to depict as a function of time a plurality of locations along an ultrasound beam axis at which blood flow is detected, the color of the color region having its intensity vary as a function of detected Doppler ultrasound amplitude; and

a spectrogram coupled to the display controller to depict detected blood flow velocities as a function of time at a selected one of the plurality of locations.

21. The graphical display of claim 20 wherein the color region has one of first and second colors corresponding with first and second detected blood flow directions.

22. The graphical display of claim of claim 20 wherein the color region has one of first and second colors corresponding with first and second detected blood flow directions, the intensity of the color varying as a function of detected blood flow velocity and Doppler ultrasound signal amplitude.

23. The graphical display of claim 20, further comprising a location indicator identifying the selected location.

24. The graphical display of claim 23 wherein the location indicator is a pointer directed towards a position within the color region corresponding to the selected location.

25. The graphical display of claim 23 wherein the location indicator is a pointer directed towards a position within the colored region corresponding to the selected location, and wherein the colored region has one of first and second colors corresponding with first and second detected blood flow directions, the intensity of the color varying as a function of detected blood flow velocity and Doppler ultrasound signal amplitude.

26. The graphical display of claim 20 wherein the blood locator display and the spectrogram are displayed simultaneously.

27. The graphical display of claim 20 wherein the plurality of locations is a first plurality and wherein the graphical display indicates a second plurality of locations along the ultrasound beam axis at which blood flow is not detected.

28. A Doppler ultrasound system for processing ultrasound signals along an ultrasound beam axis and for displaying information to a user concerning blood flow, comprising:

an ultrasound transducer operable to detect ultrasound signals and responsively produce corresponding electrical signals;

signal processing circuitry coupled with the transducer and operable to receive the electrical signals and determine blood flow characteristics corresponding with the detected ultrasound signals;

a display coupled with the signal processing circuitry and operable to provide aiming graphical information indicating as a function of time a plurality of locations along the beam axis at which blood flow is detected by varying intensity as a function of detected Doppler ultrasound am amplitude at each of the locations, and to further provide spectral graphical information indicating blood flow velocities at a selected one of the locations indicated by the aiming graphical information.

29. The Doppler ultrasound system of claim 28 wherein the aiming graphical information includes a color region corresponding with the locations at which blood flow is detected, the color associated with blood flow direction and having varying intensity as a function of one of detected blood flow velocity and detected Doppler ultrasound signal strength.

30. The Doppler ultrasound system of claim 28 wherein the display provides the aiming and spectral graphical information simultaneously.

31. The Doppler ultrasound system of claim 28, wherein the display further comprises a location indicator identifying the selected location.

32. The Doppler ultrasound system of claim 31 wherein the location indicator is a pointer directed towards a position within the display region corresponding to the selected location.

33. The Doppler ultrasound system claim 28 wherein the plurality of locations is a first plurality and wherein the graphical display indicates a second plurality of locations along the ultrasound beam axis at which blood flow is not detected.

34. In a Doppler ultrasound system for processing ultrasound signals along an ultrasound beam axis, a method of providing information to a user concerning blood flow, comprising:

displaying first graphical information depicting as a function of time blood flow at a plurality of locations along the beam axis by varying intensity as a function of detected Doppler ultrasound amplitude at each of the locations; and

displaying second graphical information depicting blood flow velocities at a selected one of the locations displayed by the first graphical information.

35. The method of claim 34 wherein displaying the first graphical information includes displaying a location indicator directed to the selected location.

36. The method of claim 34 wherein the selected location is determined by the user.

37. The method of claim 34 wherein displaying the first graphical information includes displaying a color region corresponding with locations where blood flow is detected.

38. The method of claim 34 wherein displaying the first graphical information includes displaying color having a varying intensity in correspondence with detected Doppler ultrasound signal amplitude.

39. The method of claim 34 wherein displaying the first graphical information includes displaying one of first and second colors corresponding to blood flow in first and second directions, respectively.

40. The method of claim 34 wherein displaying the first graphical information includes displaying one of first and second colors corresponding to blood flow in first and second directions, respectively, and varying the intensity of the first and second colors in correspondence with detected blood flow velocities and detected Doppler ultrasound amplitude.

41. The method of claim 34 wherein displaying the first graphical information includes displaying one of first and second colors corresponding to blood flow in first and second directions, respectively, and varying the intensity of the first and second colors in correspondence with detected Doppler ultrasound signal amplitude.

42. The method of claim 34 wherein the first and second graphical information are displayed simultaneously.

43. The method of claim 34 wherein the plurality of locations is a first plurality and wherein the graphical display indicates a second plurality of locations along the ultrasound beam axis at which blood flow is not detected.

44. In a Doppler ultrasound system for processing ultrasound signals along an ultrasound beam axis, a method of detecting and characterizing emboli in blood flow, comprising:

determining a first plurality of locations along the beam axis in which blood flows and determining a second plurality of locations along the beam axis in which blood does not flow;

determining the direction in which the blood flows at each of the first locations; and

if a first ultrasound signal having an intensity greater than a threshold intensity is received, then;

determining if the first ultrasound signal corresponds with the first locations;

determining if the first ultrasound signal corresponds with the second locations;

determining if the first ultrasound signal corresponds with the determined direction and velocity of the blood flow;

if the first ultrasound signal does not correspond with the determined direction or velocity of the blood flow, then identifying the first ultrasound signal as a non-embolic signal;

if the first ultrasound signal corresponds with the determined direction or velocity of the blood flow, and if the first ultrasound signal corresponds solely with the first locations, then identifying the first ultrasound signal as an embolic signal of a first type; and

if the first ultrasound signal corresponds with the determined direction and velocity of the blood flow, and if the first ultrasound signal corresponds both with the first and second locations, then identifying the first ultrasound signal as an embolic signal of a second type.

45. The method of claim 44, further comprising selecting one of the first locations, and wherein the first ultrasound signal is a signal corresponding with the selected location.

46. The method of claim 44 wherein determining the first plurality of locations in which blood flows includes displaying graphical information having a color region corresponding to the first locations.

47. The method of claim 44 wherein determining the first plurality of locations in which blood flows includes displaying graphical information having a color region corresponding to the first locations, and wherein determining the direction in which the blood flows at each of the first locations includes selecting one of first and second colors for the color region, the first and second colors corresponding with first and second blood flow directions along the beam axis, respectively.

48. The method of claim 44 wherein determining the first plurality of locations in which blood flows includes displaying graphical information having a color region corresponding to the first locations, and varying the intensity of the color as a function of detected Doppler ultrasound signal intensity, and wherein determining if the first ultrasound signal corresponds with the first locations includes displaying a graphical event signal corresponding with the first ultrasound signal and determining if the graphical event signal is positioned within the color region.

49. The method of claim 44 wherein determining the first plurality of locations in which blood flows includes displaying graphical information having a color region corresponding to the first locations, and varying the intensity of the color as a function of detected Doppler ultrasound signal intensity, and wherein determining if the first ultrasound signal corresponds with the determined direction and velocity of blood flow includes displaying a graphical event signal corresponding with the first ultrasound signal and determining if the graphical event signal is positioned in a predetermined orientation relative to the color region.

50. The method of claim 44 wherein determining if the first ultrasound signal corresponds with the determined direction and velocity of blood flow includes determining if the first ultrasound signal corresponds with a velocity not exceeding a maximum velocity of the blood flow.

51. In a Doppler ultrasound system for processing ultrasound signals along an ultrasound beam axis, a method of locating a selected one of a plurality of blood vessels, comprising:

determining a plurality of locations along the beam axis in which blood flows;

displaying first graphical information depicting the locations at which blood flow is detected;

determining the velocity with which blood flows in each of the locations;

selecting a first one of the locations;

displaying second graphical information depicting blood flow velocities at the first location;

detecting a temporal variation in the first graphical information;

detecting a temporal variation in the second graphical information; and

determining whether the detected temporal variations in the first and second graphical information corresponds with the selected blood vessel.

52. The method of claim 51 wherein displaying the first graphical information includes displaying a color region corresponding with the locations at which blood flow is detected.

53. The method of claim 51 wherein displaying the first graphical information includes displaying a color region corresponding with the locations at which blood flow is detected, and varying the intensity of the color as a function of detected Doppler ultrasound signal intensity.

54. The method of claim 51 wherein displaying the first graphical information includes displaying a color region corresponding with the locations at which blood flow is detected, and varying the intensity of the color as a function of the determined blood flow velocities.

55. The method of claim 51 wherein displaying the first graphical information includes displaying a color region corresponding with the locations at which blood flow is detected, and wherein detecting a temporal variation in the first graphical information includes detecting a temporal variation in the size of the color region.

56. The method of claim 51 wherein displaying the first graphical information includes displaying a color region corresponding with the locations at which blood flow is detected, and varying the intensity of the color as a function of the determined blood flow velocities, and wherein detecting a temporal variation in the first graphical information includes detecting a temporal variation in the color intensity of the color region.

57. A computer readable medium whose contents configure a computer system to provide information to a user concerning blood flow detected by processing Doppler ultrasound signals along an ultrasound beam axis, comprising:

displaying first graphical information depicting as a function of time blood flow at a plurality of locations along the beam axis by varying intensity as a function of detected Doppler ultrasound amplitude at each of the locations; and

displaying second graphical information depicting blood flow velocities at a selected one of the plurality of locations.

58. The computer readable medium of claim 57 wherein displaying the first graphical information includes displaying a location indicator directed to the selected location.

59. The computer readable medium of claim 57 wherein the selected location is determined by a user of the computer system.

60. The computer readable medium of claim 57 wherein displaying the first graphical information includes displaying a color region corresponding with locations where blood flow is detected.

61. The computer readable medium of claim 57 wherein displaying the first graphical information includes displaying color having a varying intensity in correspondence with detected Doppler ultrasound signal amplitude.

62. The computer readable medium of claim 57 wherein displaying the first graphical information includes displaying one of first and second colors corresponding to blood flow in first and second directions, respectively.

63. The computer readable medium of claim 57 wherein displaying the first graphical information includes displaying one of first and second colors corresponding to blood flow in first and second directions, respectively, and varying the intensity of the first and second colors in correspondence with detected blood flow velocities and detected Doppler ultrasound amplitude.

64. The computer readable medium of claim 57 wherein displaying the first graphical information includes displaying one of first and second colors corresponding to blood flow in first and second directions, respectively, and varying the intensity of the first and second colors in correspondence with detected Doppler ultrasound signal amplitude.

65. The computer readable medium of claim 57 that further configure the computer system to display the first and second graphical information simultaneously.

66. The user interface of claim 57 wherein the plurality of locations is a first plurality and wherein the graphical display indicates a second plurality of locations along the ultrasound beam axis at which blood flow is not detected.