Cassette and applicator for biological and chemical sample collection

• US 6,196,979 B1
• Filed: 08/24/1998
• Issued: 03/06/2001
• Est. Priority Date: 08/24/1998
• Status: Expired due to Fees

• Current Assignee: Vindur Technologies, Inc.
• Original Assignee: Burstein Technologies, Inc.
• Inventors: Virtanen, Jorma A.
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US09/139,213
• Time in Patent Office: 925 Days
• Field of Search: 600/562, 600/564-567, 600/573, 600/576, 600/583, 600/584, 422/58, 422/68.1
• US Class Current: 600/573
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150175 Adjustment of penetration depth
• CPC Class Codes: A61B 5/150259 Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150473 Double-ended needles, e.g. used with pre-evacuated sampling tubes hollow piercing element tip design A61B5/150396; needle sets for catheters A61M25/06; needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/150755 Blood sample preparation for further analysis, e.g. by separating blood components or by mixing
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/154 Devices using pre-evacuated means
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
• CPC Class Codes: G01N 35/00069 whereby the sample substrate is of the bio-disk type, i.e. having the format of an optical disk

Abstract

A biological sample collection unit for a centrifugal analyzer disk is disclosed. This unit consists of a flat cassette and an applicator that holds and controls the cassette during sample collection and during placement of the cassette into the analyzer disk.

Claims

1. An apparatus for collecting a biological sample from a subject for subsequent transfer to a CD or DVD, said apparatus comprising:

(a) a cassette comprising walls which define a cavity for receiving said biological sample, said cassette being adapted to engage said CD or DVD;

(b) an inlet for transferring said biological sample from the subject into said cavity; and

(c) an outlet for transferring said biological sample from said cavity to said CD or DVD when said cassette is engaged with said CD or DVD.

2. An apparatus according to claim 1 wherein said cassette comprises a mechanical rectifier which locks said cassette in engagement with said CD or DVD.

3. An apparatus according to claim 1 wherein said inlet comprises a conduit having a first end for penetrating said subject and a second end for penetrating the wall of said cassette which defines said cavity.

4. An apparatus according to claim 1 which further comprises a reagent or washing solution for said sample.

5. An apparatus according to claim 1 which further comprises an electrical component or microelectromechanical component.

6. An apparatus according to claim 1 which further comprises an applicator for housing said cassette prior to engagement of said cassette with said CD or DVD.

7. A CD or DVD comprising:

(A) a disk body having a surface adapted to engage an apparatus which contains a biological sample for transfer to said CD or DVD; and

(B) an apparatus engaged with said surface of said disk body, said apparatus comprising;

(a) a cassette comprising walls which define a cavity for containing said biological sample;

(b) an inlet for introducing said biological sample into said cavity prior to engagement of said apparatus with said surface of said disk body; and

(c) an outlet for transferring said biological sample from said cavity to said CD or DVD when said apparatus is engaged with said surface of said disk body.

8. A CD or DVD according to claim 7 wherein said cassette comprises a mechanical rectifier which locks said cassette in engagement with said surface of said disk body.

9. A CD or DVD according to claim 7 wherein said inlet comprises a conduit having a first end for receiving said biological sample and a second end for penetrating the wall of said cassette which defines said cavity.

10. A CD or DVD according to claim 7 wherein said apparatus further comprises a reagent or washing solution for said sample.

11. A CD or DVD according to claim 7 wherein said apparatus further comprises an electrical component or microelectromechanical component.

12. A method for transferring a biological sample from a subject to a CD or DVD, said method comprising the steps of:

transferring the biological sample from the subject to a cavity of a cassette;

engaging said cassette with a CD or DVD; and

transferring the biological sample from said cassette to said CD or DVD.

13. A method according to claim 12 wherein said cassette further comprises a reagent or washing solution, said method comprising the step of contacting said reagent or washing solution with said biological sample located with said cavity of said cassette.

14. A method according to claim 12 which comprises the step of locking said cassette in engagement with said CD or DVD.

15. A method according to claim 12 wherein said cassette further comprises a conduit having a first end and a second end, wherein said method comprises the steps of penetrating said subject with said first end and penetrating a wall of said cavity of said cassette with said second end to provide transfer of said biological sample from said subject to said cavity.

16. A method according to claim 12 wherein said cassette further comprises an electrical component or microelectromechanical component, said method comprising the step of treating said biological sample located in said cavity of said cassette with said electrical component or said microelectrochemical component.