Method and apparatus for drug and gene delivery

• US 6,197,013 B1
• Filed: 11/06/1996
• Issued: 03/06/2001
• Est. Priority Date: 11/06/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Vascular, Inc. (Medtronic Plc)
• Original Assignee: Setagon, Inc. (Medtronic Plc)
• Inventors: Feldman, Marc D., Reed, Michael L., Wu, Clarence C., Weiss, Lee E.
• Primary Examiner(s): Nguyen, A. T.
• Application Number:
  US08/743,902
• Time in Patent Office: 1,581 Days
• Field of Search: 604/49, 604/508, 604/509, 604/103.01, 604/103.02, 604/183, 604/191, 623/1, 606/108, 606/198
• US Class Current: 604/509
• CPC Class Codes: A61F 2/848 having means for fixation to the vessel wall, e.g. barbs
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 37/0015 by using microneedles

Abstract

An apparatus for treating a patient. The apparatus includes a deployment mechanism having a surface. The apparatus also includes at least one probe disposed on the deployment mechanism surface. The probe extends between 25 microns and 1000 microns from the surface of the deployment mechanism. The apparatus also includes material coated on the probe. A method for treating a patient. The method includes the steps of placing a material with a probe which extends less than 1000 microns from a surface of a deployment mechanism. Next, there is the step of inserting the probe into preferably a blood vessel of a patient. Then, there is the step of penetrating the interior wall of the vessel from the interior of the vessel with the probe by activating the deployment mechanism so the material can contact the vessel.

Claims

1. A method for treating restenosis in a vessel of a patient comprising the steps of:

placing a material with a probe, said probe extending outwardly from its central axis less than 1000 microns from an outer surface of a deployment mechanism;

inserting the probe into a vessel of patient;

activating the deployment mechanism;

penetrating the interior wall of the vessel from the interior of the vessel with the probe on the outer surface of the deployment mechanism so the material can contact the vessel; and

delivering the material to the vessel wall.

2. A method as described in claim 1 wherein the inserting step includes the step of inserting the probe into a blood vessel of a patient.

3. A method as described in claim 2 wherein the penetrating step includes the step of expanding a balloon of the deployment mechanism on which the probe is disposed until the probe pierces the interior of the vessel wall.

4. A method as described in claim 3 wherein the placing step includes the step of coating the material on the surface of the probe.

5. A method as described in claim 4 wherein the coating step includes the step of putting DNA on the surface of the probe, where the surface is made of gold or a material which is both conductive and to which DNA adheres.

6. A method as described in claim 4 including after the penetrating step, there is the step of removing the probe from the vessel.

7. A method as described in claim 4 wherein the coating step includes the step of coating the material with hydrogel or other biocompatible material which provides a protective coating to drugs or DNA.

8. A method as described in claim 3 wherein the placing step includes the step of filling a reservoir on the inside of the probe with the material.

9. A method as described in claim 1 wherein after the inserting step there is the step of opening a housing in which the probe is disposed, said housing protecting the probe and material from body fluid in the patient.