Medicinal preparation containing a lipophilic inert gas

• US 6,197,323 B1
• Filed: 03/10/1998
• Issued: 03/06/2001
• Est. Priority Date: 03/10/1997
• Status: Expired due to Fees

• Current Assignee: Michael Georgieff
• Original Assignee: Michael Georgieff
• Inventors: Georgieff, Michael
• Primary Examiner(s): Azpuru, Carlos A.
• Application Number:
  US09/037,523
• Time in Patent Office: 1,092 Days
• Field of Search: 424/423, 514/816, 514/937
• US Class Current: 424/423
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 9/0026 Blood substitute; Oxygen transporting formulations; Plasma extender
• CPC Class Codes: A61K 9/0029 Parenteral nutrition; Parenteral nutrition compositions as drug carriers
• CPC Class Codes: A61M 16/085 Gas sampling
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/43 Composition of exhalation
• CPC Class Codes: A61M 2230/437 the anaesthetic agent concentration
• CPC Class Codes: A61P 21/02 Muscle relaxants, e.g. for tetanus or cramps
• CPC Class Codes: A61P 23/00 Anaesthetics
• CPC Class Codes: A61P 23/02 Local anaesthetics
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/02 for peripheral neuropathies
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/20 Hypnotics; Sedatives
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

A preparation is described which contains a lipophilic gas with a pharmacological action in dissolved or dispersed form. This preparation is particularly suitable for inducing anaesthesia.

Claims

1. Liquid preparation for inducing and/or maintaining anaesthesia, comprising a lipophilic inert gas in a concentration effective as an anaesthetic.

6. Liquid preparation according to claim 1, comprising xenon in dissolved or dispersed form.

7. Preparation according to claim 1 which is in the form of a perfluorocarbon emulsion.

8. Preparation according to claim 1 which is in the form of a fatty emulsion including an oil-in-water emulsion or dispersion and a liposomal emulsion.

9. Preparation according to claim 1 in which another pharmacological agent is additionally present in dissolved form.

10. Preparation according to claim 9 wherein the additional pharmacologically active agent is an intravenous anaesthetic, analgesic, sedative or muscle relaxant.

11. Preparation according to claim 10 wherein the additional pharmacologically active agent is 2,6-diisopropylphenol, etomidate or a derivative thereof.

12. Preparation according to claim 10 wherein the additional pharmacologically active agent is fentanyl or alfentanil.

13. Infusion agent for anaesthesia, which comprises a preparation according to claim 1.

2. Liquid preparation for inducing sedation, comprising a lipophilic inert gas in a concentration effective as a sedative.

3. Liquid preparation for inducing analgesia, comprising a lipophilic inert gas in a concentration effective as an analgesic.

4. Liquid preparation for inducing muscular relaxation, comprising a lipophilic inert gas in a concentration effective as a muscle relaxant.

5. Liquid preparation for inflammation therapy, comprising a lipophilic inert gas in a concentration effective as an anti-inflammatory.

14. Method for inducing and/or maintaining anaesthesia wherein a liquid preparation comprising a lipophilic inert gas in a concentration effective as an anaesthetic is administered to a patient in need of anaesthesia.

15. Method for inducing sedation wherein a liquid preparation comprising a lipophilic inert gas in a concentration effective as a sedative is administered to a patient in need of sedation.

16. Method for inducing and/or maintaining analgesia wherein a liquid preparation comprising a lipophilic inert gas in a concentration effective as an analgetic is administered to a patient in need of anaesthesia.