Method for determining analytes in body fluids and also a new implantable measurement device

• US 6,198,950 B1
• Filed: 03/11/1999
• Issued: 03/06/2001
• Est. Priority Date: 03/13/1998
• Status: Expired due to Fees

• Current Assignee: Siemens Healthcare Diagnostics Products GmbH (Siemens AG)
• Original Assignee: Dade Behring Marburg GmbH (Siemens AG)
• Inventors: Kraus, Michael
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/265,883
• Time in Patent Office: 726 Days
• Field of Search: 600/309, 600/310, 600/317, 600/322, 600/341, 600/345, 600/352, 600/364, 128/903
• US Class Current: 600/317
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors
• CPC Class Codes: Y10S 128/903 Radio telemetry

Abstract

The present invention relates to an implantable diagnostic apparatus for determining analytes in body fluids, which comprises a plurality of identical and/or different measurement units for determining an analytic parameter, in which a signal is generated which is specifically related to the variable to be determined and is transmitted by means of suitable measures to a receiver situated outside the body.

Claims

1. A diagnostic apparatus for determining analytes in body liquids, which comprises

(i) at least one measurement unit for single or continuous determination of an analyte, wherein the measurement unit contains at least one measurement chamber and generates a signal in the presence of the analyte to be determined and wherein the measurement chamber(s) contain(s) photosensitizers;

(ii) at least one signal transmission unit capable of converting the signal and forwarding it to a signal-processing unit or capable of forwarding the unconverted signal to a signal-processing unit; and

(iii) at least one sample feeder to each measurement unit which is adapted to extend into the relevant liquid-containing body compartment.

2. The apparatus as claimed in claim 1, wherein a light source which radiates a light suitable for exciting photosensitizers projects into at least one measurement chamber of said measurement unit(s).

3. The apparatus as claimed in claim 1 or 2, wherein a surface within the measurement chamber(s) of said measurement unit(s) is/are at least partly conductive.

4. The apparatus as claimed in claim 3, wherein the analytes react with photosensitizers in such a way that the photosensitizers yield, depending on the analyte'"'"'s concentration or activity, singlet oxygen, wherein said singlet oxygen is measured by electrodes and converted into a transmittable signal.

5. The apparatus as claimed in claim 1, wherein the measurement chamber(s) contain(s) photosensitizers capable of producing oxygen radicals after illumination.

6. The apparatus as claimed in claim 5, wherein the photosensitizers are sensitizer beads.

7. The apparatus as claimed in claim 1, wherein the liquid-containing body compartment is a blood vessel.

8. The apparatus as claimed in claim 1, wherein the measurement unit(s) is/are adapted to be implanted outside of a blood vessel.

9. The apparatus as claimed in claim 1, wherein said apparatus does not exceed an external volume of 1500 μ

l.

10. The apparatus as claimed in claim 1, wherein the apparatus comprises a plurality of measurement units, and which is adapted for use in determining one single analyte.

11. The apparatus as claimed in claim 1, wherein the apparatus comprises a plurality of measurement units, and which is adapted for use in determining different analytes.

12. The apparatus as claimed in claim 1, wherein the energy necessary for at least one of either signal generation or transmission is generated by a concomitantly implanted battery.

13. The apparatus as claimed in claim 1, wherein the energy necessary for at least one of either signal generation or transmission is fed in by an external transducer.

14. The apparatus as claimed in claim 4, wherein in the presence of analytes the signal is generated by photosensitizers that are in close proximity with acceptors and the singlet oxygen generated by the photosensitizers activates said acceptors which subsequently produce light, and said light is detected.

15. The apparatus as claimed in claim 14, wherein the acceptors are acceptor beads.

16. Method for determining analytes or their activity using an apparatus as claimed in claim 1, the method comprising the steps if:

(a) reacting the analytes with photosensitizers in such a way that the photosensitizers yield, depending on the analyte'"'"'s concentration or activity, singlet oxygen;

(b) measuring said singlet oxygen;

(c and converting said measurements into a transmittable signal.

17. A method for determining analytes or their activity using a diagnostic apparatus as claimed in claim 1, the method comprising the steps of:

(a) generating a signal in the presence of analytes with photosensitizers that are in close proximity with acceptors;

(b) activating said acceptors with singlet oxygen generated by said photosensitizers which subsequently produce light;

(c) and detecting said light.

18. A method according to claims 16 or 17 used for the detection of hemostasis disturbances.