Method and apparatus for combining injury-mediated therapy and drug delivery
First Claim
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1. A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, said method comprising the steps of:
- i) creating a track to tissue injury in said tissue, and ii) injecting into said tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecule, wherein the track of the injection is in a predetermined direction relative to but not within, said tack of tissue injury, said method resulting in improvement of a condition of said disease to a greater degree than results from injury-induced revascularization treatment alone.
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Abstract
A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, such as coronary artery disease, is described. The method involves (i) creating injury in a tissue (e.g., muscle, such as cardiac muscle) by, for example, use of a laser, an ultrasonic device, or a Thermal probe, and (ii) injecting into the tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecules Also described is an apparatus that can be used to practice this method.
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Citations
28 Claims
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1. A method of enhancing injury-induced revascularization of a tissue as treatment of a disease, said method comprising the steps of:
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i) creating a track to tissue injury in said tissue, and ii) injecting into said tissue a revascularization-promoting molecule or a nucleic acid molecule encoding a revascularization-promoting molecule, wherein the track of the injection is in a predetermined direction relative to but not within, said tack of tissue injury, said method resulting in improvement of a condition of said disease to a greater degree than results from injury-induced revascularization treatment alone. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of increasing expression of a gene in a tissue, said method comprising the steps of;
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i) creating a track tissue injury in said tissue, and ii) injecting into said tissue a nucleic acid molecule comprising said gene, wherein the track of the injection is in a predetermined direction relative to buy within said track of tissue injury, said method resulting in increased expression of said gene compared to expression that results firm injection of said nucleic acid molecule alone. - View Dependent Claims (23, 24, 25, 26, 27, 28)
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Specification