Pharmaceutical compositions containing chondroitinase and uses therefor

• US 6,200,564 B1
• Filed: 04/10/1998
• Issued: 03/13/2001
• Est. Priority Date: 04/11/1997
• Status: Expired due to Term

• Current Assignee: Select Therapeutics, Inc.
• Original Assignee: Bhaskar K. Ramakrishnan, Lamont J. Thomas
• Inventors: Green, Allan M., Bhaskar, K. Ramakrishnan, Lamont, J. Thomas
• Primary Examiner(s): TATE, CHRISTOPHER ROBIN
• Application Number:
  US09/058,684
• Time in Patent Office: 1,068 Days
• Field of Search: 424/94.1, 424/94.6, 424/94.61, 514/851
• US Class Current: 424/94.61
• CPC Class Codes: A61K 38/51 Lyases (4)
• CPC Class Codes: A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
• CPC Class Codes: C12Q 1/527 involving lyase
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

Gastrointestinal mucus from patients suffering from cystic fibrosis has been found to contain large amounts of chondroitin sulfate polymer. This finding indicates that the enzyme chondroitinase is useful for preventing gastrointestinal mucus from accumulating in cystic fibrosis patients, and subjects suffering from other diseases or conditions characterized by excess mucus secretion.

Claims

1. A method for treating a subject having a disorder characterized by the accumulation of mucoid secretions, comprising administering to the subject a therapeutically effective amount of an agent that prevents chondroitin sulfate accumulation such that treatment of the subject occurs, wherein the agent is a chondroitinase enzyme.

2. The method of claim 1, wherein the agent prevents chondroitin sulfate accumulation by degrading the chondroitin sulfate.

3. The method of claim 2, wherein the disorder is a pulmonary disorder.

4. The method of claim 3, wherein the pulmonary disorder is cystic fibrosis.

5. The method of claim 2, wherein the disorder is a pancreatobiliary disorder.

6. The method of claim 5, wherein the pancreatobiliary disorder is biliary cirrhosis.