Hydrocolloid wound gel

• US 6,201,164 B1
• Filed: 01/11/1999
• Issued: 03/13/2001
• Est. Priority Date: 07/11/1996
• Status: Expired due to Term

• Current Assignee: Coloplast A/S
• Original Assignee: Coloplast A/S
• Inventors: Aagren, Sven Per Magnus, Nielsen, Peter Sylvest, Wulff, Trine
• Primary Examiner(s): Brown, Michael A.
• Assistant Examiner(s): HAMILTON, LALITA M
• Application Number:
  US09/147,506
• Time in Patent Office: 792 Days
• Field of Search: 602/48, 602/41, 602/43
• US Class Current: 602/48
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 15/60 Liquid-swellable gel-forming materials, e.g. super-absorbents
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 1/00 Compositions of cellulose, modified cellulose or cellulose derivatives
• CPC Class Codes: C08L 1/08 Cellulose derivatives
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 5/04 Alginic acid; Derivatives thereof

Abstract

A hydrocolloid gel composition, especially a wound gel composition, which comprises: a) a water insoluble, water swellable cross-linked cellulose derivative; b) an alginate; and c) distilled water in a sufficient amount to make up the difference between the amount of ingredients a)+b) and 100% and wherein the gel comprises from 0.05 to 5.00% by weight of alginate, shows better absorption capacity than known gels, accelerates the healing by serving as a slow-release system for active ingredients promoting wound healing.

Claims

1. A method for preparing a hydrocolloid gel formulation wherein a cross-linked water-swellable cellulose derivative powder is mixed dry with alginate powder and then water is admixed.

2. A method as claimed in claim 1 wherein the mixing is carried out using a dissolver.

3. Use of an amorphous hydrocolloid gel composition which comprises

a. a water insoluble, water swellable cross-linked cellulose derivative

b. an alginate;

and

c. distilled water in a sufficient amount to make up the difference between the amount of ingredients a.+b. and 100% and wherein the gel comprises from 0.05 to 5.00% by weight of alginate and from 2.00 to 8.00% by weight of cross-linked water swellable cellulose derivative for debridement of necrotic tissue in a wound and for speeding up the healing of the wound.

4. Use of an amorphous hydrocolloid gel composition which comprises

a. a water insoluble, water swellable cross-linked cellulose derivative

b. an alginate;

and

c. distilled water in a sufficient amount to make up the difference between the amount of ingredients a.+b. and 100% and wherein the gel comprises from 0.05 to 5.00% by weight of alginate and from 2.00 to 8.00% by weight of cross-linked water swellable cellulose derivative as vehicle for transplantation of cells to a wound.

5. A hydrocolloid gel composition which comprises

a. a water insoluble, water swellable, cross-linked cellulose derivative;

b. an alginate; and

c. distilled water in a sufficient amount to make up the difference between the amount of ingredients a+b and 100% such that the gel includes from 0.05 to 5.00% by weight of the alginate and from 2.00 to 8.00% by weight of the water insoluble, water swellable cross-linked cellulose derivative.

6. A hydrocolloid gel composition as claimed in claim 5 which includes from 3 to 5% by weight of the water insoluble, water swellable, cross-linked cellulose derivative.

7. A hydrocolloid gel composition as claimed in claim 6 wherein the gel composition is a wound gel composition.

8. A hydrocolloid gel composition as claimed in claim 5 which includes from 0.5 to 1.00% by weight of the alginate.

9. A hydrocolloid gel composition as claimed in claim 8 wherein the gel composition is a wound gel composition.

10. A hydrocolloid gel composition as claimed in claim 5 which further includes an active ingredient.

11. A hydrocolloid gel composition as claimed in claim 10 wherein the gel composition is a wound gel composition.

12. A hydrocolloid gel composition as claimed in claim 5 wherein the gel composition is a wound gel composition.