Blood fluid characteristics analysis instrument

• US 6,201,607 B1
• Filed: 08/20/1999
• Issued: 03/13/2001
• Est. Priority Date: 04/13/1998
• Status: Expired due to Fees

• Current Assignee: Trividia Health, Inc. (Sinocare, Inc.)
• Original Assignee: MIT Development Corp (Sinocare, Inc.)
• Inventors: Roth, G. Thomas, Paolini, Gregory P.
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): MERLINO, AMANDA H
• Application Number:
  US09/379,130
• Time in Patent Office: 571 Days
• Field of Search: 356/445-448, 356/39-43
• US Class Current: 356/445
• CPC Class Codes: G01N 21/47 Scattering, i.e. diffuse reflection G01N21/25, G01N21/41 take precedence G01N21/55 takes precedence
• CPC Class Codes: G01N 21/78 producing a change of colour
• CPC Class Codes: G01N 21/8483 Investigating reagent band test-element handling not specific to a test method G01N33/4875; analytical elements specific to chemical analysis of biological material G01N33/52; autometer with reagent band G01N35/04

Abstract

An apparatus for enhancing the analysis of light reflected from a blood exposed reagent is described. Light from sources, such as LED'"'"'s, is used to detect the levels of glucose and fructosamine in the blood exposed reagent. A special optical arrangement is used to obtain optical signals indicative of the optically sensitive chemicals in the reagent. The optical beams from respective LED'"'"'s are directed at a common surface of an optical element used to redirect the light onto the reagent and reflect portions onto a reference detector. A main detector is strategically located adjacent a surface of the optical element to detect reflections from the reagent. A control circuit is described with which the light from the LED light sources can be held at substantially constant levels despite factors tending to cause light level changes.

Claims

1. A diagnostic instrument for generating a signal indicative of the level of a chemical in a body fluid sample using a reagent strip with a reagent which undergoes a color change when exposed to a fluid sample, comprising:

a housing having a surface for receiving reagent strips and having an optical aperture through which an optical beam from inside the housing can illuminate the reagent on the strip;

an optical beam generating structure positioned inside the housing and producing said optical beam through said optical aperture with light from a reagent strip being reflected back through said aperture for detection;

said optical beam generating structure further including;

a first light source producing an optical beam directed toward said reagent strip,

a reference photo detector located to detect a portion of the optical beam;

a main photo detector located to detect reflections caused by the incidence of the optical beam onto said reagent strip;

a control circuit coupled to said light source and said reference detector to maintain the light output from said light source substantially constant; and

wherein said reference detector and said main detectors are so selected that a sensitivity versus wavelength characteristic of said main detector is different from a sensitivity versus wavelength characteristic of said reference detector, said reference detector being selected so that its sensitivity as a function of wavelength is sufficient to super-impose on the control circuit a compensation for changes in the wavelength of the light source and attributable to changes in the light source'"'"'s drive current or operating temperature.

2. The diagnostic instrument as claimed in claim 1 wherein said reference detector is selected with a sensitivity versus wavelength characteristic that increases, at a different rate, as the wavelength from the light source increases toward longer wavelengths in comparison with the sensitivity versus wavelength characteristic for said main detector.

3. The diagnostic instrument as claimed in claim 1 and further including a control loop responsive to output signals from said reference detector and coupled to drive the optical beam generating structure in a direction so as to maintain optical power from said light beam generating structure substantially constant.

4. The diagnostic instrument as claimed in claim 1 wherein said reference detector is selected so as to have a blue wavelength enhanced sensitivity.

5. The diagnostic instrument as claimed in claim 1 wherein said reference detector includes an optical filter selected to provide said blue wavelength enhanced sensitivity.