Method of prevention and treatment of atherosclerosis and article of manufacture therefor
First Claim
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1. A method of treating atherosclerosis, comprising:
- applying an electrical impulse proximal to a blood vessel of a person, at a rate and amplitude effective to inhibit the development of an atherosclerotic plaque in the vessel.
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Abstract
A method and system for preventing or treating atherosclerosis are provided in which a blood vessel susceptible to or containing atherosclerotic plaque is subjected to a low-frequency electrical impulse at an effective rate and amplitude to prevent or impede the establishment or decrease the size of the plaque in the vessel. The system can be implanted into the body of a patient or applied externally to the skin.
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Citations
37 Claims
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1. A method of treating atherosclerosis, comprising:
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applying an electrical impulse proximal to a blood vessel of a person, at a rate and amplitude effective to inhibit the development of an atherosclerotic plaque in the vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 30, 31, 33, 34, 35, 36, 37)
implanting an electrical lead to an electric pulse generator into the muscle on one side of the blood vessel;
implanting the electric pulse generator on an opposite side of the blood vessel; and
generating the electrical impulse from the electric pulse generator through the electrical lead into the muscle.
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10. The method of claim 1, further comprising:
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implanting an electrical lead to an electric pulse generator into a muscle on one side of the blood vessel;
implanting the pulse generator on the same side of the blood vessel as the electric lead; and
generating the electrical impulse from the electric pulse generator through the electrical lead into the muscle.
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11. The method of claim 1, further comprising:
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implanting an electrical lead to an electric pulse generator into connective tissue proximal to the blood vessel;
implanting the electric pulse generator on an opposite side of the blood vessel; and
generating an electrical current flow from the electric pulse generator through the electrical lead, wherein an electric field is created around the vessel.
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12. The method of claim 1, further comprising:
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positioning an electrical lead to an electric pulse generator on the skin of the patient and in proximity to the muscle;
positioning the electric pulse generator external to the skin of the patient and in proximity to the vessel; and
generating an electrical current flow from the electric pulse generator through the electrical lead and the skin of the patient to the muscle.
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13. The method of claim 1, comprising:
- applying the electrical impulse to effectively decrease the size of the atherosclerotic plaque.
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14. The method of claim 1, comprising:
- applying a low frequency electrical impulse of about 2-20 Hz and an amplitude of about 1-6 V.
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15. The method of claim 1, comprising:
- applying a low frequency electrical impulse of about 8-10 Hz and an amplitude of about 2.5-3.0 V.
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16. The method of claim 1, comprising:
- applying the electrical impulse at intervals during a treatment period.
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17. The method of claim 1, further comprising:
- measuring and comparing the size of the atherosclerotic plaque in the blood vessel before and after applying the electrical impulse.
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18. The method of claim 1, further comprising:
- measuring and comparing the blood flow through the blood vessel before and after applying the electric impulse.
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19. The method of claim 1, comprising:
- applying the electrical impulse to reduce the atherosclerotic plaque by about 25-95%.
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20. The method of claim 1, comprising:
- applying the electrical impulse to reduce the atherosclerotic plaque by about 75-90%.
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21. The method of claim 1, comprising:
- applying the electrical impulse to increase bloodflow through the blood vessel by about 25-50%.
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22. The method of claim 1, wherein the blood vessel is selected from the group consisting of abdominal aorta, coronary artery, thoracic aorta, femoral artery, and a peripheral artery.
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23. A system for treating atheroschlerosis according to the method of claim 1, comprising:
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a) a member for generating an electrical impulse and programmed to generate a low-frequency electrical impulse of about 2-20 Hzat about 30-120 beats per minute, and an amplitude of about 1-6 V; and
b) an electrical lead for transmitting the electrical impulse proximal to a blood vessel being treated.
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24. The system of claim 23, wherein the pulse generating member is programmed to generate a low-frequency electrical impulse of about 8-10 Hz and an amplitude of about 2.5-3.0 V.
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25. The system of claim 23, wherein at least one of the pulse generating member and the electric lead is implantable in the body of the patient.
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26. The system of claim 23, wherein at least one of the pulse generating member and the electric lead can be applied externally to the skin of the patient.
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27. The system of claim 23, wherein the pulse generating member is operable to be reprogrammed to modify the rate and amplitude of the generated electrical impulse.
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30. The method of claim 24, comprising:
- applying the electrical impulse at a rate and amplitude effective to generate an electrical field around the blood vessel.
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31. The method of claim 24, comprising:
- applying the electrical impulse to a muscle proximal to the blood vessel at a rate and amplitude effective to cause the muscle to contract, to generate an electrical field around the blood vessel, or both.
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33. The method of claim 27, comprising:
- applying the electrical impulse at a rate and amplitude effective to generate an electrical field around the blood vessel.
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34. The method of claim 27, comprising:
- applying the electrical impulse to a muscle proximal to the blood vessel at a rate and amplitude effective to cause the muscle to contract, to generate an electrical field around the blood vessel, or both.
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35. An article of manufacture, packaged together, for use for treating atherosclerosis in a patient, comprising:
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a) a member for generating an electrical impulse and programmable to generate a low-frequency electrical impulse of about 2-20 Hz and an amplitude of about 1-6 V;
b) an electrical lead for transmitting the electrical impulse proximal to a blood vessel being treated in the body; and
c) instructions for use of the pulse generating member and the electric lead in treating atherosclerosis according to the method of claim 1.
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36. The article of claim 35, wherein at least one of the pulse generating member and the electric lead is implantable in the body of the patient.
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37. The system of claim 35, wherein at least one of the pulse generating member and the electric lead can be applied externally to the skin of the patient.
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28. A method of treating atherosclerosis, comprising:
applying an electrical impulse to a muscle proximal to a blood vessel of a person, at a rate and amplitude effective to stimulate contraction of the muscle and generate an electric field around the vessel, and inhibit the development of an atherosclerotic plaque in the vessel.
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29. A method of preventing atherosclerosis, comprising:
applying an electrical impulse proximal to a blood vessel of a person, at a rate and amplitude effective to prevent the development of an atherosclerotic plaque in the vessel.
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32. A method of decreasing an atherosclerotic plaque in a vessel of a person, comprising:
- subjecting an area of atherosclerotic plaque in a blood vessel to a low-frequency electrical impulse at a rate and amplitude effective to decrease the size of the plaque in the vessel.
Specification