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Method and system for pattern analysis, such as for analyzing oligonucleotide primer extension assay products

  • US 6,203,990 B1
  • Filed: 04/09/1999
  • Issued: 03/20/2001
  • Est. Priority Date: 11/06/1998
  • Status: Expired due to Fees
First Claim
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1. A system for generating information based on biological samples, comprising:

  • a biological assay device that analyzes a two dimensionally spaced set of biological samples and produces a set of data therefrom, wherein the biological samples include at least one control sample, wherein the set of data includes x-axis and y-axis spatial coordinate values and a quantitative value for each biological sample, and wherein the set of data may include unwanted values; and

    a computer having a processor and memory, wherein the computer receives the set of data from the biological assay device, stores the set of data in the memory, and wherein the processor;

    determines a two dimensional location of the at least one control sample based on the set of data;

    identifies x-axis and y-axis spatial coordinates for the biological samples in the set of data based on the determined two dimensional location of the at least one control sample;

    filters the quantitative values of for at least some of the biological samples, from the unwanted values, in the set of data, based on the identified x-axis and y-axis spatial coordinates; and

    analyzes the filtered quantitative values of each biological sample, respectively, by comparing the quantitative value of a first portion of the filtered quantitative values of each respective biological sample at a first pair of x-axis and y-axis spatial coordinates with a sum of the quantitative value of the first portion and the quantitative value of a second portion of the filtered quantitative values of each respective biological sample at a second pair of x-axis and y-axis spatial coordinates to produce a displayable report of the analyzed quantitative values.

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