Coated intraluminal graft

• US 6,206,916 B1
• Filed: 07/29/1999
• Issued: 03/27/2001
• Est. Priority Date: 04/15/1998
• Status: Expired due to Term

• Current Assignee: Mirus LLC
• Original Assignee: Joseph G. Furst
• Inventors: Furst, Joseph G.
• Primary Examiner(s): TRUONG, KEVIN THAO
• Application Number:
  US09/363,052
• Time in Patent Office: 607 Days
• Field of Search: 623/1.11, 623/1.16, 623/1.15, 623/1.27, 623/1.39, 623/1.46, 623/1.44
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/91533 characterised by the phase between adjacent bands
• CPC Class Codes: A61F 2002/91566 connected trough to trough
• CPC Class Codes: A61F 2002/91575 connected peak to trough
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/08 Materials for coatings
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

An expandable intraluminal graft for use within a body cavity having a tubular shaped member with two ends and a wall surface disposed between the ends. The tubular shaped member has a first diameter to permit intraluminal delivery of the member into a body cavity, and a second expanded diameter. Coated on the surface of the tubular shaped member is a substance that inhibits and/or reduces restenosis, vascular narrowing and/or in-stent restenosis.

Claims

1. An intraluminal graft for use within in a body cavity including a geometrically shaped member and a biological agent, said geometrically shaped member having first and second ends and a wall surface disposed between the first and second ends, the wall surface being formed by a plurality of intersecting elongated members, at least some of the elongated members intersecting with one another intermediate the first and second ends of the geometrically shaped member, said geometrically shaped member having a first diameter which permits intraluminal delivery of the geometrically shaped member into a body cavity, and a second expanded diameter, said biological agent being at least partially coated on the surface of said geometrically member, said biological agent including a compound to inhibit or reduce a biological condition selected from the group consisting of restenosis, vascular narrowing, in-stent restenosis and combinations thereof, at least a portion of said biological agent releasably coated on a surface of said graft.

2. The expandable intraluminal graft as defined in claim 1, wherein said biological agent includes a platelet inhibitor.

3. The expandable intraluminal graft as defined in claim 2, wherein said platelet inhibitor includes Trapidil.

4. The expandable intraluminal graft as defined in claim 3, wherein said body cavity is selected from the group consisting of a body passageway, body duct or a body blood vessel.

5. The expandable intraluminal graft as defined in claim 4, wherein said second diameter is variable.

6. The expandable intraluminal graft of claim 5, wherein the plurality of elongated members are a plurality of wires, and the wires are fixedly secured to one another where the wires intersect with one another.

7. The expandable intraluminal graft of claim 5, wherein the plurality of elongated members are a plurality of thin bars which are fixedly secured to one another where the bars intersect with one another.

8. The expandable intraluminal graft of claim 5, wherein said geometrically shaped member includes a plurality of openings.

9. The expandable intraluminal graft of claim 5, wherein said graft includes two geometrically shaped members and at least one connector connected between the two geometrically shaped members, said connector allowing transverse bending flexibility of said graft.

10. The expandable intraluminal graft of claim 5, wherein said geometrically shaped member includes material to make the geometrically shaped member visible under fluoroscopy.

11. The expandable intraluminal graft as defined in claim 10, wherein said geometrically shaped member is at least partially coated with a material that is visible under fluoroscopy.

12. The expandable intraluminal graft as defined in claim 11, wherein said material is coated on at least one end of said geometrically shaped member.

13. The expandable intraluminal graft of claim 12, wherein said intersecting elongated members are formed by etching and/or laser cutting.

14. The expandable intraluminal graft of claim 13, including a mounting substance to be at least partially coated on said graft, said mounting substance at least partially securing said biological agent to said graft.

15. The expandable intraluminal graft as defined in claim 14, wherein said mounting substance at least partially delays delivery of said biological agent into said body cavity.

16. The expandable intraluminal graft as defined in claim 15, including balloon, said balloon including at least one opening to allow delivery of said biological substance from an interior of said balloon to said body cavity.

17. The expandable intraluminal graft as defined in claim 16, wherein said biological substance includes said biological agent.

18. The expandable intraluminal graft of claim 17, wherein said geometrically shaped member is treated with Gamma or Beta radiation to reduce the vascular narrowing of at least a portion of said body cavity.

19. The expandable intraluminal graft of claim 18, wherein said geometrically shaped member is substantially tubular.

20. The expandable intraluminal graft as defined in claim 5, wherein said geometrically shaped member is at least partially coated with a material that is visible under fluoroscopy.

21. The expandable intraluminal graft as defined in claim 2, wherein said second diameter is variable.

22. The expandable intraluminal graft of claim 2, including a mounting substance to be at least partially coated on said graft, said mounting substance at least partially securing said biological agent to said graft.

23. The expandable intraluminal graft as defined in claim 22, wherein said mounting substance at least partially delays delivery of said biological agent into said body cavity.

24. The expandable intraluminal graft as defined in claim 23, including balloon, said balloon including at least one opening to allow delivery of said biological substance from an interior of said balloon to said body cavity.

25. The expandable intraluminal graft as defined in claim 24, wherein said biological substance includes said biological agent.

26. The expandable intraluminal graft as defined in claim 22, including balloon, said balloon including at least one opening to allow delivery of said biological substance from an interior of said balloon to said body cavity.

27. The expandable intraluminal graft as defined in claim 26, wherein said biological substance includes said biological agent.

28. The expandable intraluminal graft as defined in claim 2, including balloon, said balloon including at least one opening to allow delivery of said biological substance from an interior of said balloon to said body cavity.

29. The expandable intraluminal graft as defined in claim 28, wherein said biological substance includes said biological agent.

30. The expandable intraluminal graft as defined in claim 1, wherein said body cavity is selected from the group consisting of a body passageway, body duct or a body blood vessel.

31. The expandable intraluminal graft as defined in claim 1, wherein said second diameter is variable.

32. The expandable intraluminal graft of claim 1, wherein the plurality of elongated members are a plurality of wires, and the wires are fixedly secured to one another where the wires intersect with one another.

33. The expandable intraluminal graft of claim 1, wherein the plurality of elongated members are a plurality of thin bars which are fixedly secured to one another where the bars intersect with one another.

34. The expandable intraluminal graft of claim 1, wherein said geometrically shaped member includes a plurality of openings.

35. The expandable intraluminal graft of claim 1, wherein said graft includes two geometrically shaped members and at least one connector connected between the two geometrically shaped members, said connector allowing transverse bending flexibility of said graft.

36. The expandable intraluminal graft of claim 1, wherein said geometrically shaped member includes material to make the geometrically shaped member visible under fluoroscopy.

37. The expandable intraluminal graft as defined in claim 1, wherein said geometrically shaped member is at least partially coated with a material that is visible under fluoroscopy.

38. The expandable intraluminal graft as defined in claim 37, wherein said material is coated on at least one end of said geometrically shaped member.

39. The expandable intraluminal graft of claim 1, wherein said intersecting elongated members are formed by etching and/or laser cutting.

40. The expandable intraluminal graft of claim 1, including a mounting substance to be at least partially coated on said graft, said mounting substance at least partially securing said biological agent to said graft.

41. The expandable intraluminal graft as defined in claim 40, wherein said mounting substance at least partially delays delivery of said biological agent into said body cavity.

42. The expandable intraluminal graft as defined in claim 1, including balloon, said balloon including at least one opening to allow delivery of said biological substance from an interior of said balloon to said body cavity.

43. The expandable intraluminal graft as defined in claim 42, wherein said biological substance includes said biological agent.

44. The expandable intraluminal graft of claim 1, wherein said geometrically shaped member is treated with Gamma or Beta radiation to reduce the vascular narrowing of at least a portion of said body cavity.

45. The expandable intraluminal graft of claim 1, wherein said geometrically shaped member is substantially tubular.