Hydrophilic adhesive masses

• US 6,207,184 B1
• Filed: 06/11/1999
• Issued: 03/27/2001
• Est. Priority Date: 06/18/1998
• Status: Expired due to Term

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: SSP Company Limited (Sanofi )
• Inventors: Okuyama, Hirohisa, Ishigaki, Kenji, Ikeda, Yasuo, Kasai, Shuichi, Imamori, Katsumi
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): GHALI, ISIS A D
• Application Number:
  US09/330,065
• Time in Patent Office: 655 Days
• Field of Search: 424/448, 424/446, 424/447, 424/443
• US Class Current: 424/448
• CPC Class Codes: A61K 9/7061 Polyacrylates
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 1/26 Cellulose ethers
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 33/02 Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• CPC Class Codes: C08L 33/04 Homopolymers or copolymers of esters C08L43/04 takes precedence
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
• CPC Class Codes: C08L 51/02 grafted on to polysaccharides
• CPC Class Codes: C09J 133/062 Copolymers with monomers not covered by C09J133/06

Abstract

A hydrophilic adhesive mass contains 0.05 to 10 wt. % of a copolymer of an aminoalkyl (meth)acrylate and an alkyl (meth)acrylate. This hydrophilic adhesive mass is excellent in adhesiveness, and especially when combined with a pharmacologically active ingredient, is suitable for use in providing hydrophilic plasters.

Claims

1. A hydrophilic plaster comprising a backing;

and a paste formed of a hydrophilic adhesive mass, comprising 0.05 to 10 wt. % of a copolymer of an aminoalkyl (meth)acrylate and an alkyl (meth)acrylate and a cross linking agent selected from the group consisting of aluminum compounds, magnesium compounds and calcium compounds, and spread on said backing.

2. The hydrophilic plaster according to claim 1, wherein an amine moiety in said aminoalkyl (meth)acrylate has been obtained from a tertiary amine or a quaternary ammonium salt.

3. The hydrophilic plaster according to claim 1, wherein an amine moiety in said aminoalkyl (meth)acrylate has been obtained from dimethylamine or trimethylammonium chloride.

4. The hydrophilic plaster according to claim 1, further comprising at least one hydrophilic adhesive selected from the group consisting of polyacrylic acid and salts thereof, copolymers obtained using acrylic acid or salts thereof, and cellulose derivatives and salts thereof.

5. The hydrophilic plaster according to claim 4, wherein said at least one hydrophilic adhesive is selected from the group consisting of polyacrylic acid, sodium polyacrylate, crosslinked branched polyacrylic acid, crosslinked branched sodium polyacrylate, crosslinked product of acrylic acid-starch graft copolymer, N-vinylacetamide-sodium acrylate copolymer, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, hydrophobized hydroxypropylmethylcellulose, and carboxymethylcellulose sodium.

6. The hydrophilic plaster according to claim 1, further comprising, as a solubilizer for said copolymer of said aminoalkyl (meth)acrylate and said alkyl (meth)acrylate, at least one ingredient selected from the group consisting of polyhydric alcohols, fatty acid esters, surfactants, fatty acids, alcohols and hydrocarbons.

7. The hydrophilic plaster according to claim 1, wherein water is contained in a proportion of from 1 to 85 wt. %.

8. The hydrophilic plaster according to claim 1, further comprising at least one ingredient selected from the group consisting of skin penetration enhancers and humectants.

9. The hydrophilic plaster according to claim 1, wherein the paste additionally contains at least one pharmacologically active ingredient.

10. The hydrophilic plaster according to claim 9, wherein said at least one pharmacologically active ingredient is selected from the group consisting of analgesic antiphlogistics, antifungal agents, drugs for urinary incontinence, skeletal muscular relaxants, antispasmodics, cardiacs, smoking cessation aids, antiallergic drugs, topical anesthetics, antiseptic disinfectants and skin irritants.