Disposable premoistened wipe containing an antimicrobial protease inhibitor

• US 6,207,596 B1
• Filed: 11/09/1998
• Issued: 03/27/2001
• Est. Priority Date: 11/09/1998
• Status: Expired due to Fees

• Current Assignee: The Procter & Gamble Company
• Original Assignee: The Procter & Gamble Company
• Inventors: Richards, Marc Frederic, Osborne, Scott Edward, Rourke, Francis James
• Primary Examiner(s): Copenheaver, Blaine
• Assistant Examiner(s): TORRES VELAZQUEZ, NORCA LIZ
• Application Number:
  US09/188,442
• Time in Patent Office: 869 Days
• Field of Search: 442/123
• US Class Current: 442/123
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 37/52 containing groups, e.g. carboxylic acid amidines
• CPC Class Codes: A01N 39/00 Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or , e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
• CPC Class Codes: A61K 2800/782 Enzyme inhibitors; Enzyme antagonists
• CPC Class Codes: A61K 8/0208 Tissues; Wipes; Patches
• CPC Class Codes: A61K 8/40 containing nitrogen quinones containing nitrogen A61K8/355
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

A disposable wipe which comprises a substrate, an antimicrobial protease inhibitor, and a liquid. The antimicrobial protease inhibitor may be added directly to the substrate and/or added directly to the liquid. The antimicrobial protease inhibitor is capable of inhibiting deleterious fecal microorganisms and protease enzymes thereby aiding in the prevention of diaper dermatitis. The wipe may optionally include other ingredients examples of which include humectants, emollients, surfactants, fragrances, emulsifiers, and preservatives.

Claims

1. A premoistened wipe comprising:

a nonwoven fibrous substrate including from about 0.5 grams to 8 grams of liquid per gram of dry fiber in said substrate and from about 0.004% to 10% antimicrobial protease inhibitor by weight of dry fiber in said substrate wherein said antimicrobial protease inhibitor is an aromatic diamidine, said aromatic diamidine having the formula;

wherein X is H or OH, and

wherein n=3 to 12 and X is Cl, I, Br, F or H

wherein said aromatic diamidine is hexamidine diisethionate.

2. The premoistened wipe of claim 1 wherein said liquid includes a solvent comprising at least about 50% of said liquid by weight, wherein said solvent is oil, alcohol, water, and mixtures thereof and wherein said liquid further comprises from about 0.0005% to 10% hexamidine diisethionate by weight of said liquid.

3. A premoistened wipe comprising:

a nonwoven fibrous substrate including from about 0.5 grams to 8 grams of liquid per gram of dry fiber said liquid further comprising;

a) a solvent comprising at least about 50% of said liquid by weight, said solvent selected from the group consisting of oil, alcohol, water, and mixtures thereof; and

b) at least one Antimicrobial protease inhibitor comprising from about 0.0005% to 10% of said liquid by weight wherein said antimicrobial protease inhibitor is an aromatic diamidine said aromatic diamidine having the formula;

wherein X is H or OH, and

wherein n=3 to 12 and X is Cl, I, Br, F or H

wherein said aromatic diamidine is hexamidine diisethionate.

4. The premoistened wipe of claim 3 wherein said liquid further comprises:

a) an optional humectant(s) comprising from about 0.5% to 10% of said liquid by weight, said humectant(s) selected from the group consisting of glycerin, sorbitol, phospholipids, propylene glycol and mixtures thereof;

b) an optional emollient(s) comprising from about 0.1% to 10% of said liquid by weight, wherein said emollient(s) is selected from the group consisting of fatty acid esters, alkyl ethoxylates, fatty acid ester ethoxylates, fatty alcohols, polysiloxanes, mucopolysaccharides, or mixtures thereof;

c) an optional surfactant(s) comprising from about 0.01% to 10% of said liquid by weight, said surfactant(s) selected from the group consisting of nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants, zwitterionic surfactants, and mixtures thereof; and

d) an optional preservative(s) comprising from about 0.01% to 1% of said liquid by weight, said preservative(s) selected from the group consisting of methylparaben, propylparaben, and 2-Bromo-2-nitropropane-1,3 Diol, and mixtures thereof.