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Dextromethorphan and oxidase inhibitor for weaning patients from narcotics and anti-depressants

  • US 6,207,674 B1
  • Filed: 12/22/1999
  • Issued: 03/27/2001
  • Est. Priority Date: 12/22/1999
  • Status: Expired due to Term
First Claim
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1. A method of weaning a patient from long-term use of a habit-forming narcotic drug, comprising administering to the patient a combination of dextromethorphan and a second drug which suppresses oxidation of dextromethorphan by cytochrome oxidase enzyme P450-2D6, wherein:

  • a. the second drug is administered at an effective concentration which increases measurable levels of dextromethorphan in the patient'"'"'s blood;

    b. the dextromethorphan is administered at a therapeutically effective concentration which, when coadministered with the second drug, allows the patient to reduce his or her dosage of a habit-forming narcotic drug, without intolerable adverse effects, during a gradual weaning process; and

    , c. the dextromethorphan and the second drug are co-administered to the patient in a manner which allows the patient to decrease and then stop taking the habit-forming narcotic drug without suffering intolerable adverse effects.

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