Bioabsorbable branched polymer containing units derived from dioxanone and medical/surgical devices manufactured therefrom

• US 6,207,767 B1
• Filed: 11/26/1997
• Issued: 03/27/2001
• Est. Priority Date: 07/22/1994
• Status: Expired due to Term

• Current Assignee: United States Surgical Corporation (Medtronic Plc)
• Original Assignee: United States Surgical Corporation (Medtronic Plc)
• Inventors: Gruskin, Elliott A., Bennett, Steven L., Connolly, Kevin M., Jiang, Ying
• Primary Examiner(s): Buttner, David J.
• Application Number:
  US08/979,009
• Time in Patent Office: 1,217 Days
• Field of Search: 528/68, 528/73, 528/81, 525/411, 525/413, 525/415, 523/116, 523/118, 523/122, 427/2.31, 424/426
• US Class Current: 525/415
• CPC Class Codes: A61B 17/08 Wound clamps or clips, i.e. not or only partly penetrating the tissue suture bridges A61B17/0466; Devices for bringing together the edges of a wound
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 17/58 for osteosynthesis, e.g. bone plates, screws , setting implements or the like A61B17/14, A61B17/16 take precedence
• CPC Class Codes: A61L 17/12 Homopolymers or copolymers of glycolic acid or lactic acid
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08G 63/06 derived from hydroxycarboxylic acids
• CPC Class Codes: C08G 63/912 derived from hydroxycarboxylic acids
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

Star polymers of soft segment forming monomers are useful in forming surgical devices. The star polymers can be encapped with isocyanate, mixed with a filler and/or cross-linked. The polymer compositions are useful, for example, as fiber coatings, surgical adhesives or bone putty, or tissue growth substrate.

Claims

1. A method comprising:

a) providing a star polymer having the general formula;

2. A method as in claim 1 further comprising forming a surgical device which is made at least in part of said bioabsorbable crosslinked polymer.

3. A method as in claim 1 wherein said step of forming a surgical device comprises applying the endcapped polymer of step (b) to a substrate and cross-linking the endcapped polymer.

4. A method as in claim 1 further comprising mixing the endcapped polymer of step (b) with a filler.

5. A method as in claim 2 wherein said filler is a bioceramic.

6. A method as in claim 1 further comprising the step of incorporating a medico-surgically useful substance into the polymer.

7. A method as in claim 1 wherein the isocyanate used is diisocyanato lysine ethyl ester.

8. A biocompatible composition comprising crosslinked prepolymer molecules, the prepolymer molecules having at least one reactive isocyanate group, the prepolymer molecules comprising a star polymer of the general formula:

9. A composition as in claim 8 wherein Z comprising a combination of repeating units of

10. A composition as in claim 8 further comprising a filler.

11. A composition as in claim 10 wherein said polymer is cross-linked to entrap at least a portion of said filler.

12. A composition as in claim 9 having a putty-link consistency.

13. A composition as in claim 8 wherein Z at each occurrence is

14. A composition as in claim 8 wherein Z comprises a combination of repeating units of

15. A biocompatible composition comprising crosslinked prepolymer molecules, the prepolymer molecules having at least one reactive isocyanate group, the prepolymer molecules comprising a star polymer of the general formula:

16. A composition as in claim 15 wherein Z at each occurrence is

17. A substrate for tissue growth comprising a star polymer of the general formula:

18. A substrate for tissue growth as in claim 17 wherein the positively-charged group is a diethylaminoethyl group.

19. A substrate for tissue growth as in claim 18 wherein Z comprises repeating units of