BMP-6 proteins

• US 6,207,813 B1
• Filed: 11/09/1998
• Issued: 03/27/2001
• Est. Priority Date: 07/01/1986
• Status: Expired due to Fees

• Current Assignee: Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: Genetics Institute LLC (Pfizer Inc.)
• Inventors: Wozney, John M., Wang, Elizabeth A., Rosen, Vicki A., Celeste, Anthony J.
• Primary Examiner(s): ROMEO, DAVID S
• Application Number:
  US09/189,157
• Time in Patent Office: 869 Days
• Field of Search: 536/23.5, 530/350
• US Class Current: 536/23.5
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: C08L 89/00 Compositions of proteins; Compositions of derivatives thereof foodstuff preparations A23J3/00
• CPC Class Codes: C12N 15/85 for animal cells
• CPC Class Codes: Y10S 530/84 Bones; tendons; teeth; cartilage

Abstract

Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.

Claims

1. An isolated DNA molecule encoding a BMP-6 protein said DNA comprising nucleotides #1321 to #1698 of FIG. 3.

2. An isolated DNA molecular encoding a BMP-6 protein said DNA comprising the nucleotide sequences of ATCC #68245 encoding BMP-6.

3. An isolated DNA molecule encoding a BMP-6 protein said DNA comprising the nucleotide sequence of ATCC #68021 encoding BMP-6. vp