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Fluorescent dyes (AIDA) for solid phase and solution phase screening

  • US 6,207,831 B1
  • Filed: 12/21/1998
  • Issued: 03/27/2001
  • Est. Priority Date: 12/21/1998
  • Status: Expired due to Fees
First Claim
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1. Compounds represented by formula (I) whereinone of the radicals R1 or R2 and one of the radicals R3 or R4 is hydrogen and the other is independently —

  • COOH, —

    COOR7, —

    CONH2, —

    CONH(CH2),OH, wherein n=2-8, —

    CONR8R9, —

    CH2OH, —

    CH2NH2, —

    NO2, NR10OR11, NHCOR12, Cl, Br, F, —

    CF3, —

    N=C=O, N=C=S, —

    SO3H, —

    SO2NH(CH2)nNH2, (C1-C4) alkyl, (C1-C16)-alkyl substituted at the terminal carbon with —

    COOH, —

    COOR7, —

    CONH2, —

    CONR8R9, —

    CONH(CH2)nOH, wherein n=2-8, —

    CH2OH, —

    CH2NH2, —

    N=C=O, N=C=S, —

    SO3H, —

    SO2NH(CH2)nNH2, —

    CONH(CH2)nNH2 wherein n=2-8, and the NH2-group could also be substituted by (C1-C4) alkyl or a commonly used amino protecting group, and one of the radicals R5 or R6 is hydrogen and the other is hydrogen, halogen, —

    NO2, NR10OR11, NHCOR12, (C1-C4) alkyl, (C1-C16)-alkyl substituted at the terminal carbon with —

    COOH, —

    COOR7, —

    CONH2, —

    CONR8R9, —

    CONH(CH2)nOH, wherein n=2-8, —

    CH2OH, —

    CH2NH2 , —

    N=C=O, N=C=S, —

    SO3H, —

    SO2NH(CH2)nNH2, —

    CONH(CH2)nNH2 wherein n=2-8, and the NH2-group could also be substituted by (C1-C4) alkyl or a commonly used amino protecting group, with the proviso that only one of R1-R6 is nitro, R7 is a commonly used carboxyl protecting or carboxyl activating group, R8 or R9 is hydrogen and the other is lower alkyl (C1-C4), phenyl, benzyl, or R8 and R9 are part of a 5 or 6 membered ring, R10 and R11 are independently hydrogen or (C1-C4)alkyl, and R12 is (C1-C10)alkyl or phenyl, which both can be substituted by (C1-C4) alkyl, protected amino group or halogen.

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