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Non-linear optical tomography of turbid media

DC
  • US 6,208,886 B1
  • Filed: 04/03/1998
  • Issued: 03/27/2001
  • Est. Priority Date: 04/04/1997
  • Status: Expired due to Term
First Claim
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1. An apparatus for use in constructing a three-dimensional tomographic map of a sample, said apparatus comprising:

  • (a) means for scanning the sample with a focused beam of laser light in x, y and z directions, said light emerging from the sample comprising fundamental light, at least second-order harmonic wave light, and fluorescence due to multi-photon excitation;

    (b) means for selectively passing only said at least second-order harmonic wave light and said fluorescence due to multi-photon excitation;

    (c) means for individually detecting each of said at least second-order harmonic wave light and said fluorescence due to multi-photon excitation selectively passed; and

    (d) means for generating a three-dimensional tomographic map of the sample using the light detected by said detecting means.

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