Catheter-delivered low resolution Raman scattering analyzing system for detecting lesions
First Claim
1. A system for detecting the presence of a lesion in a lumen of a subject using low resolution Raman spectroscopy comprising:
- a catheter comprising an excitation fiber through which multi-mode radiation can propagate to irradiate a target region of a lumen;
a multi-mode laser for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation;
a low resolution dispersion element positioned to receive and separate the scattered radiation into different wavelength components;
a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and
a processor for processing data from the detector array.
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Abstract
The present invention provides low resolution Raman spectroscopic systems and methods for in-vivo detection and analysis of a lesion in a lumen of a subject. The system uses a multi-mode laser attached to a catheter in making in-vivo Raman spectroscopic measurements of the lumen. The system includes a light collector and/or a light dispersion element as well as a detector to measure spectral patterns that indicate the presence of the lesion. Based on the spectral response of the lumen, the presence (or absence) of a lesion can be determined. In addition, the components of the lesion can also be identified based on the unique Raman spectrum associated with each component.
348 Citations
21 Claims
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1. A system for detecting the presence of a lesion in a lumen of a subject using low resolution Raman spectroscopy comprising:
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a catheter comprising an excitation fiber through which multi-mode radiation can propagate to irradiate a target region of a lumen;
a multi-mode laser for irradiating the target region to produce a Raman spectrum consisting of scattered electromagnetic radiation;
a low resolution dispersion element positioned to receive and separate the scattered radiation into different wavelength components;
a detection array, optically aligned with the dispersion element for detecting at least some of the wavelength components of the scattered light; and
a processor for processing data from the detector array. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for detecting the presence of a lesion in a lumen of a subject using low resolution Raman spectroscopy comprising:
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providing a catheter comprising an excitation fiber through which multi-mode radiation can propagate, the excitation fiber having a first end optically coupled to a multi-mode laser, and a second end positioned in optical alignment with a light directing element to direct radiation to a site within a lumen;
inserting the catheter into the lumen;
activating the multi-mode laser to irradiate the lumen to produce a Raman spectrum consisting of scattered electromagnetic radiation;
collecting a portion of the scattered radiation;
separating the collected radiation into different wavelength components using a low resolution dispersion element;
detecting at least some of the wavelength components of the scattered light using a detection array; and
processing the data from the detection array to detect the presence of a lesion. - View Dependent Claims (16, 17, 18, 19, 20, 21)
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Specification