Microsensor for determination of glucose and other analysis in liquids based on affinity viscosimetry
First Claim
1. A microsensor for the determination of concentration of glucose or other analytes in liquids, based on microsystem technology and viscosity measurement of an analyte-sensitive polymer solution enclosed in a dialysis hollow fiber suitable for implantation in the human body, comprising a hollow conductor;
- a closed circuit of at least One liquid in said hollow conductor said dialysis hollow fiber containing said analyte-sensitive polymer solution;
an analyte concentration measuring system, said hollow conductor combining said dialysis hollow chamber and said analyte-concentration measuring system, said analyte-concentration measuring system including a micromotor for moving said analyte-sensitive polymer solution, said at least one liquid transducing forces between said micromotor and said analyte-sensitive polymer solution within said dialysis hollow fiber, and a Signal transducer operatively connected to said micromotor to generate Signals unequivocally related to viscosity of said analyte-sensitive polymer solutions said signal transducer being selected from the group consisting of a pressure-sensitive signal transducer, a volume-sensitive signal transducer, and a flow-sensitive signal transducer.
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Abstract
A microsensor for the determination of glucose and other analytes in liquids, based on affinity viscosimetry. The sensor based on affinity viscosimetry with stable working properties can be sufficiently minaturized for implantation in the organism. The sensor has a completely closed liquid conducting system having a dialysis chamber of a dialysis hollow fiber filled with the aqueous polymer system, and a measuring system for electrical signal transduction working in such a way that the sensitive polymer solution and eventually other liquids which are not miscible but hydraulically coupled with the polymer solution, are able to move on a closed path. The measuring system contains a micromotor to induce the liquid movement and a signal transducer sensitive to either pressure, volume or streaming to form signals related unequivocally to viscosity.
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Citations
12 Claims
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1. A microsensor for the determination of concentration of glucose or other analytes in liquids, based on microsystem technology and viscosity measurement of an analyte-sensitive polymer solution enclosed in a dialysis hollow fiber suitable for implantation in the human body, comprising a hollow conductor;
- a closed circuit of at least One liquid in said hollow conductor said dialysis hollow fiber containing said analyte-sensitive polymer solution;
an analyte concentration measuring system, said hollow conductor combining said dialysis hollow chamber and said analyte-concentration measuring system, said analyte-concentration measuring system including a micromotor for moving said analyte-sensitive polymer solution, said at least one liquid transducing forces between said micromotor and said analyte-sensitive polymer solution within said dialysis hollow fiber, and a Signal transducer operatively connected to said micromotor to generate Signals unequivocally related to viscosity of said analyte-sensitive polymer solutions said signal transducer being selected from the group consisting of a pressure-sensitive signal transducer, a volume-sensitive signal transducer, and a flow-sensitive signal transducer.
- a closed circuit of at least One liquid in said hollow conductor said dialysis hollow fiber containing said analyte-sensitive polymer solution;
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2. A microsensor for the determination of concentration of glucose or other analytes in liquids, based on microsystem technology and viscosity measurement of an analyte-sensitive polymer solution enclosed in a dialysis hollow fiber, comprising a hollow conductor;
- a closed circuit of at least one liquid in said hollow conductor said dialysis hollow fiber containing said analyte-sensitive polymer solution;
an analyte concentration measuring system, said hollow conductor combining said dialysis hollow chamber and said analyte-concentration measuring system, said analyte-concentration measuring system including a micromotor for moving said analyte-sensitive polymer solution, said at least one liquid transducing forces between said micromotor and said analyte-sensitive polymer solution within said dialysis hollow fiber, and a signal transducer operatively connected to said micromotor to generate signals unequivocally related to viscosity of said analyte-sensitive polymer solution said signal transducer being selected from the group consisting of a pressure-sensitive signal transducer, a volume-sensitive signal transducer, and a flow-sensitive signal transducer. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- a closed circuit of at least one liquid in said hollow conductor said dialysis hollow fiber containing said analyte-sensitive polymer solution;
Specification