Intracorporeal microwave warming method and apparatus

• US 6,210,367 B1
• Filed: 08/04/1999
• Issued: 04/03/2001
• Est. Priority Date: 09/06/1995
• Status: Expired due to Term

• Current Assignee: Coral Sand Beach, LLC
• Original Assignee: Microwave Medical Systems Incorporated (General Electric Company)
• Inventors: Carr, Kenneth L.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US09/368,179
• Time in Patent Office: 608 Days
• Field of Search: 604/114, 604/113, 604/500, 604/19, 604/28, 219/687, 219/688, 219/689
• US Class Current: 604/114
• CPC Class Codes: A61B 18/18 by applying electromagnetic radiation, e.g. microwaves radiation therapy A61N5/00
• CPC Class Codes: A61B 18/1815 using microwaves
• CPC Class Codes: A61B 2018/1861 with an instrument inserted into a body lumen or cavity, e.g. a catheter
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61M 1/0281 Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
• CPC Class Codes: A61M 1/369 Temperature treatment
• CPC Class Codes: A61M 2205/3686 microwaves
• CPC Class Codes: A61M 5/44 having means for cooling or heating the devices or media
• CPC Class Codes: H05B 6/802 for heating fluids methods of heating fluids in conventional microwave ovens H05B6/687

Abstract

Intracorporeal warming apparatus includes a catheter for placement in a patient, the catheter having a distal end and a proximal end. An antenna lies adjacent to the distal end of the catheter and a cable having one end connected to the antenna extends from the proximal end of the catheter. A transmitter transmits a first signal of a first frequency capable of heating blood or tissue and a receiver receives a second signal of a second frequency which is indicative of thermal radiation, the receiver producing an output signal in response thereto. A diplexer connects the proximal end of the cable to the transmitter and receiver so as to couple the first signal from the transmitter only to the antenna and the second signal from the antenna only to the receiver so that the apparatus can simultaneously heat the blood or tissue and determine the actual temperature of that material. Preferably also, the catheter includes an expandable stand-off device adjacent to the antenna which can be expanded to properly position the catheter when in use. There is also provision for indicating the condition of the stand-off device, i.e., open or closed, before the apparatus is activated.

Claims

1. Intracorporeal warming apparatus comprising

an elongated catheter for placement adjacent to high dielectric/high loss organic material in a patient, said catheter having a distal end and a proximal end and including an antenna adjacent said distal end and a cable having one end connected to said antenna and a second end;

a transmitter for transmitting a first signal of a first frequency capable of heating said material;

a receiver for receiving a second signal of a second frequency indicative of thermal radiation, said receiver producing an output signal in response thereto, and

a diplexer connecting the second end of the cable to the transmitter and receiver, said diplexer coupling said first signal from said transmitter only to said antenna while coupling said second signal from said antenna only to said receiver so that the apparatus can simultaneously heat said material and determine the actual temperature of said material.

2. The apparatus defined in claim 1 wherein the receiver comprises a radiometer.

3. The apparatus defined in claim 1 wherein said catheter also includes

expandable means located adjacent to said antenna, said expandable means being movable between a contracted position wherein the expandable means lies within the cross sectional envelope of the catheter and an expanded position wherein the expandable means extends outside said envelope, and

moving means extending between said expandable means and the proximal end of the catheter for moving the expandable means between said positions.

4. The apparatus defined in claim 3 and further including means responsive to the position of the expandable means for indicating said position.

5. The apparatus defined in claim 1 wherein said antenna is a monopole.

6. The apparatus defined in claim 1 wherein said diplexer comprises

a first arm connected between the transmitter and the antenna and containing a low pass filter which passes only said first signal, and

a second arm connected between the receiver and a junction between the low pass filter and the antenna, said second arm containing a band pass filter which passes said second signal but blocks said first signal.

7. The apparatus defined in claim 6 wherein the length of the connection between the low pass filter and the junction is one-quarter of the wavelength of the second signal and the length of the connection between the band pass filter and the junction is one-quarter of the wavelength of the first signal.

8. The apparatus defined in claim 1 and further including a display responsive to said output signal for producing an indication of the actual temperature of said material.

9. The apparatus defined in claim 1 and further including control means responsive to said output signal for controlling the transmitter to heat said material according to a selected temperature/time profile.

10. An extracorporeal warming apparatus comprising an elongated, flexible catheter having a distal end and a proximal end, said catheter including

coaxial inner and outer conductors separated by a dielectric medium, said inner conductor being longer than said outer conductor so that a segment of the inner conductor projects axially beyond the outer conductor adjacent the distal end of the catheter to form an antenna;

an expandable stand-off device adjacent to said antenna, said stand-off device including a flexible sleeve encircling said distal end segment of said inner conductor, said sleeve having one end fixed relative to said conductors and a second end movable parallel to said conductors between a first position wherein said sleeve is generally cylindrical and a second position wherein said sleeve is bowed outward, and

moving means for moving the second end of the sleeve between said positions.

11. The apparatus defined in claim 10 wherein said sleeve is slitted lengthwise between said first and second ends to form a circular array of resilient ribs between said ends.

12. The apparatus defined in claim 10 wherein the moving means comprise a movable cord having one end attached to the second end of the sleeve and a second end projecting from the proximal end of the catheter so that by exerting a force on the second end of the cord, the second end of the sleeve may be moved to said second position.

13. The apparatus defined in claim 12 wherein said sleeve has a natural, unstressed state wherein said ribs are straight.

14. The apparatus defined in claim 11 wherein said sleeve has a natural, unstressed state wherein said ribs are bowed.

15. The apparatus defined in claim 10 wherein said one end of the sleeve is closer to the distal end of the catheter.

16. The apparatus defined in claim 10 wherein said one end of the sleeve is closer to the proximal end of the catheter.

17. The apparatus defined in claim 10 wherein the antenna is a monopole.

18. The apparatus defined in claim 10 wherein the antenna is a helical antenna.

19. The apparatus defined in claim 10 and further including an electrical cable having one end connected to said inner and outer conductors at the proximal end of the catheter and a second end adapted to be connected to a control and display unit.

20. The apparatus defined in claim 19 and further including a control and display unit comprising

a transmitter for transmitting a first signal at a frequency capable of heating high-dielectric/high loss organic material adjacent to the catheter;

a receiver for receiving a second signal of a second frequency and indicative of thermal radiation, said receiver producing an output signal in response thereto, and

a diplexer connecting the second end of said cable to the transmitter and receiver, said diplexer coupling said first signal from said transmitter only to said antenna while coupling said second signal from the antenna only to said receiver so that the apparatus can simultaneously heat said material and determine the actual temperature of said material.

21. The apparatus defined in claim 20 and further including a display responsive to said output signal for producing an indication of the actual temperature of said material.

22. The apparatus defined in claim 20 and further including control means responsive to said output signal for controlling the transmitter to heat said material according to a selected temperature/time profile.