Method for treating a wall of a blood vessel

• US 6,210,392 B1
• Filed: 01/15/1999
• Issued: 04/03/2001
• Est. Priority Date: 01/15/1999
• Status: Expired due to Term

• Current Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Original Assignee: Interventional Technologies Incorporated (Boston Scientific Corporation)
• Inventors: Vigil, Dennis M., Reiss, Robert E., Barath, Peter
• Primary Examiner(s): Kennedy, Sharon
• Assistant Examiner(s): MAYNARD, JENNIFER J
• Application Number:
  US09/232,392
• Time in Patent Office: 809 Days
• Field of Search: 604/19, 604/27, 604/28, 604/48, 604/500, 604/501, 604/507-509, 604/522, 604/73, 604/93, 604/96, 604/97, 604/104, 604/105, 604/107
• US Class Current: 604/507
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1086 having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence

Abstract

A method and device for injecting fluid into a treatment area of a vessel wall is provided herein. A first version of the device includes an inflatable balloon mounted on a catheter and a plurality of dispensers extending outwardly and moving with the balloon. At least one fluid passageway connects each injector in fluid communication with a fluid source. During use of the device, the balloon is first positioned in a vessel proximate the treatment area. Next, the balloon is inflated to embed the dispensers into the vessel wall. Subsequently, the fluid from the fluid source is introduced into the fluid passageway and through the dispensers into the treatment area. A second version of the device includes a plurality of flexible tubes mounted between a multi-lumen catheter and a grommet. A push-pull wire is connected to the grommet and passed through a lumen of the multi-lumen catheter. The dispensers are mounted on each of the flexible tubes. During use, the device is first positioned in a vessel. The push-pull wire is then partially withdrawn forcing the grommet to advance towards the multi-lumen catheter. The advancing grommet forces the flexible tubes to bow outwardly, embedding the dispensers into the vessel wall.

Claims

1. A method for treating a wall of a vessel, the vessel having a vessel pH level, the method comprising the steps of:

providing a fluid having a fluid pH level which is different from the vessel pH level, at least a portion of the fluid precipitating at approximately the vessel pH level; and

dispensing the fluid into the wall of the vessel to allow at least a portion of the fluid to approach the vessel pH level and precipitate.

2. The method of claim 1 wherein the step of providing a fluid includes providing a fluid including an active component which inhibits the proliferation of smooth tissue growth in the wall of the vessel.

3. The method of claim 1 wherein the step of providing a fluid includes providing a fluid which includes gold colloidal.

4. The method of claim 1 wherein the step of providing a fluid includes providing a fluid which includes a radiopharmaceutical precipitate.

5. The method of claim 1 wherein the step of providing a fluid includes providing a fluid which includes an inorganic precipitate.

6. The method of claim 1 wherein the step of providing a fluid includes providing a fluid which has a fluid pH level of less than approximately six pH.

7. The method of claim 1 wherein the step of providing a fluid includes providing a fluid which has a fluid pH level of greater than approximately eight pH.

8. The method of claim 1 wherein the step of providing a fluid includes providing a fluid including ^99mTc (Technetium 99).

9. The method of claim 1 wherein the step of providing a fluid includes providing a fluid which includes ³²P (Phosphorous 32).