Implantable members for receiving therapeutically useful compositions

• US 6,210,436 B1
• Filed: 06/03/1999
• Issued: 04/03/2001
• Est. Priority Date: 05/18/1998
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Weadock, Kevin
• Primary Examiner(s): Isabella, David J.
• Assistant Examiner(s): Koh, Choon P.
• Application Number:
  US09/325,024
• Time in Patent Office: 670 Days
• Field of Search: 623/1.39, 623/1.41, 623/23.58, 424/93.1, 424/93.2, 424/93.21, 424/422
• US Class Current: 623/1.39
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/408 Virucides, spermicides
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/42 Anti-thrombotic agents, anticoagulants, anti-platelet agents
• CPC Class Codes: A61L 2300/44 Radioisotopes, radionuclides
• CPC Class Codes: A61L 2300/64 Animal cells
• CPC Class Codes: A61L 27/38 containing added animal cells organs or tissue containing native cells A61L27/36
• CPC Class Codes: A61L 27/3808 Endothelial cells
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

An implantable prosthesis includes a porous polymeric member having pores present in its wall structure wherein these pores contain a variety of therapeutically useful compositions including, collagen, genetically altered cells and piezoelectric materials. A process of preparing such a prosthesis is also disclosed.

Claims

1. An implantable member comprising a porous polymeric substrate having a wall structure substantially free of an ePTFE node and fibril structure, said wall structure including pores filled with a fluid composition that contains one or more population of cells which is precipitated out in situ to form an insoluble biocompatible, biodegradable material therein.

2. The implantable member of claim 1, wherein said cells are transfected with a genetic construct, said cells being able to produce and release a therapeutically useful composition.

3. The implantable member of claim 2, wherein said therapeutically useful composition is selected from the group consisting thrombo-resistant agents, antibiotic agents, anti-tumor agents, growth hormones, antiviral agents, anti-angiogenic agents, angiogenic agents, anti-mitotic agents, anti-inflammatory agents, cell cycle regulating agents, hormones, their homologs, derivatives, fragments and combinations thereof.

4. The implantable member of claim 1, wherein said cells are transfected with a genetic construct which codes for a secreted form of tissue plasminogen activator.

5. The implantable member of claim 1, wherein said cells are autologously derived.

6. The implantable member of claim 1, wherein said cells are non-autologously derived.

7. The implantable member of claim 1, wherein said cells are endothelial cells.