Methods for early detection of heart disease
First Claim
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1. Method of detecting a condition which causes heart failure in a human, the method comprising the steps of:
- (a) measuring a level of a lipid, other than a lysophospholipid, cardiac marker in a test sample from said human; and
(b) determining if the level of said cardiac marker measured in said test sample correlates with a condition which causes heart failure in a human.
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Abstract
The invention relates to methods, compositions, kits, and devices for detecting cardiac ischemia, hypoxia, or other causes of heart failure in a mammal by obtaining a test sample from a mammal, measuring a level of a non-polypeptidic cardiac marker in the test sample, and determining if the level of the cardiac marker measured in said test sample correlates with cardiac ischemia or hypoxia or another form of heart failure.
283 Citations
40 Claims
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1. Method of detecting a condition which causes heart failure in a human, the method comprising the steps of:
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(a) measuring a level of a lipid, other than a lysophospholipid, cardiac marker in a test sample from said human; and
(b) determining if the level of said cardiac marker measured in said test sample correlates with a condition which causes heart failure in a human. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. Method of detecting a condition which causes heart failure in a mammal, the method comprising the steps of:
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(a) measuring a level of a lipid, other than a lysophospholipid, cardiac marker in a test sample from said mammal;
(b) measuring a level of a second cardiac marker in said test sample; and
(c) determining if the level of either or both of said cardiac markers measured in said test sample correlates with a condition which causes heart failure. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34)
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35. A method of determining prognosis of a patient following a cardiac procedure by detecting cardiac ischemia or hypoxia, the method comprising the steps of:
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(a) measuring a level of a lipid, other than a lysophospholipid, cardiac marker in a test sample from said mammal;
(b) measuring a level of a second cardiac marker in said test sample; and
(c) determining if the level of either or both of said cardiac markers measured in said test sample correlates with a condition associated with cardiac ischemia or hypoxia.
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36. Method of detecting a condition which causes heart failure in a mammal, the method comprising the steps of:
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(a) measuring a level of a lipid, other than a lysophospholipid, cardiac marker in a body fluid obtained from said mammal; and
(b) determining if the level of said lipid, other than a lysophospholipid, cardiac marker in said body fluid correlates with a condition which causes heart failure in a mammal.
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37. Method of detecting a condition which causes heart failure in a human, the method comprising the steps of:
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(a) measuring a level of a sphingolipid in a test sample from said human; and
(b) determining if the level of said sphingolipid in said test sample correlates with a condition which causes heart failure in a human.
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38. Method of detecting a condition which causes heart failure in a mammal, the method comprising the steps of:
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(a) measuring a level of a sphingolipid in a test sample from said mammal;
(b) measuring a level of a second cardiac marker in said test sample; and
(c) determining if the level of said sphingolipid and/or said second cardiac marker measured in said test sample correlates with a condition which causes heart failure.
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39. Method of detecting a condition which causes heart failure in a human, the method comprising the steps of:
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(a) measuring a level of a sphingolipid in a test sample from said human;
(b) measuring a level of a second cardiac marker in said test sample; and
(c) determining if the level of said sphingolipid and/or said second cardiac marker measured in said test sample correlates with a condition which causes heart failure.
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40. Method of detecting a condition which causes heart failure in a human, the method comprising the steps of:
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(a) measuring a level of a sphingolipid in a body fluid sample obtained from said human;
(b) measuring a level of a second cardiac marker in said body fluid sample; and
(c) determining if the level of said sphingolipid and/or said second cardiac marker measured in said body fluid sample correlates with a condition which causes heart failure.
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Specification