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Maximizing effectiveness of substances used to improve health and well being

  • US 6,214,379 B1
  • Filed: 06/01/1999
  • Issued: 04/10/2001
  • Est. Priority Date: 04/02/1998
  • Status: Expired due to Term
First Claim
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1. A drug delivery regimen, which comprises:

  • an active therapeutic substance administered during at least one 24 hour period of time to provide effective therapeutic levels of the active therapeutic substance at a site of action in an animal over said period, wherein each individual dose is independently adjusted to be administered to optimize levels of the active therapeutic substance at the site of action for maximum efficacy, and wherein the dose amount at each administration is independently determined by the formula TD(t)=CD(t)+RD(t), where t is the time at which the dose is to be administered, TD (therapeutic dose) is the therapeutically effective dose at time (t), CD (current dose) is the dose to be administered at time (t), and RD (residual dose) is the amount of active therapeutic substance remaining from the previous dose administration;

    wherein the active therapeutic substance is administered in one or more dosage form(s) independently selected from the group consisting of liquid, solution, suspension, emulsion, tablet, multi-layer tablet, capsule, gelatin capsule, caplet, lozenge, chewable lozenge, bead, powder, granules, dispersible granules, cachets, douche, suppository, cream, topical, inhalant, patch, particle inhalant, implant, ingestible, injectable, or infusion; and

    wherein the active therapeutic substance is administered in uneven doses.

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