Methods for the detection of chromosomal aberrations
First Claim
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1. A method for detecting a fetal chromosomal abnormality, comprising the steps of:
- a) introducing a first nucleic acid probe to a sample, wherein said first probe is capable of hybridizing to at least a portion of a first fetal chromosome in the sample;
b) introducing a second nucleic acid probe to the sample, wherein said second probe is capable of hybridizing to at least a portion of a second fetal chromosome;
c) washing said sample to remove unhybridized first and second probes;
d) determining a number X of said first probe that is hybridized to said first fetal chromosome or portion thereof;
e) determining a number Y of said second probe that is hybridized to said second fetal chromosome or portion thereof;
f) determining whether a difference exists between number X and number Y, the presence of a statistically-significant difference being indicative of a fetal chromosomal abnormality.
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Abstract
Methods are provided for detecting fetal chromosomal aberrations by detecting statistically-significant differences between normal and aberrant chromosomes.
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Citations
1 Claim
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1. A method for detecting a fetal chromosomal abnormality, comprising the steps of:
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a) introducing a first nucleic acid probe to a sample, wherein said first probe is capable of hybridizing to at least a portion of a first fetal chromosome in the sample;
b) introducing a second nucleic acid probe to the sample, wherein said second probe is capable of hybridizing to at least a portion of a second fetal chromosome;
c) washing said sample to remove unhybridized first and second probes;
d) determining a number X of said first probe that is hybridized to said first fetal chromosome or portion thereof;
e) determining a number Y of said second probe that is hybridized to said second fetal chromosome or portion thereof;
f) determining whether a difference exists between number X and number Y, the presence of a statistically-significant difference being indicative of a fetal chromosomal abnormality.
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Specification