Liquid enzyme compositions and methods of use in contact lens cleaning and disinfecting systems
First Claim
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1. A stable liquid enzyme composition for cleaning a contact lens comprising:
- a proteolytic enzyme in an amount effective to clean the lens;
40-85% w/v of a mixture of monomeric polyols and polyalkoxylated glycols, the glycols having molecular weights of from 200-600 daltons;
an amount of a borate/boric acid compound effective to enhance the proteolytic stability of the enzyme;
an amount of calcium ion effective to enhance the proteolytic stability of the enzyme; and
water.
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Abstract
Stable liquid enzyme compositions containing an ophthalmically acceptable enzyme and methods involving the combined use of these compositions with an antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.
41 Citations
38 Claims
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1. A stable liquid enzyme composition for cleaning a contact lens comprising:
- a proteolytic enzyme in an amount effective to clean the lens;
40-85% w/v of a mixture of monomeric polyols and polyalkoxylated glycols, the glycols having molecular weights of from 200-600 daltons;
an amount of a borate/boric acid compound effective to enhance the proteolytic stability of the enzyme;
an amount of calcium ion effective to enhance the proteolytic stability of the enzyme; and
water. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- a proteolytic enzyme in an amount effective to clean the lens;
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12. A method for cleaning and disinfecting a contact lens comprising:
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placing the lens in an aqueous disinfecting solution containing an amount of an antimicrobial agent effective to disinfect the lens;
forming an aqueous disinfectant/enzyme solution by dispersing an amount of a liquid enzyme cleaning composition in said disinfecting solution, said cleaning composition comprising;
a proteolytic enzyme in an amount effective to clean the lens;
40-85% w/v of a mixture of monomeric polyols and polyalkoxylated glycols, the glycols having a molecular weight of from 200-600 daltons;
an amount of a borate/boric acid compound effective to enhance the proteolytic stability of the enzyme;
an amount of calcium ion effective to enhance the proteolytic stability of the enzyme; and
water; and
soaking the lens in said aqueous disinfectant/enzyme solution for a period of time sufficient to clean and disinfect the lens. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
about 0.001% w/v of polyquaternium-1;
about 0.6% w/v of boric acid;
about 1.2% w/v of sorbitol;
about 0.65% w/v of sodium citrate;
about 0.1% w/v of sodium chloride;
about 0.05% w/v of poloxamine 1304;
about 0.05% w/v of disodium edetate;
about 0.45% w/v of 95% 2-amino-2methyl-1-propanol, about 0.0005% w/v of myristamidopropyl dimethyl amine; and
water.
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19. A method according to claim 12, wherein the concentration of the enzyme is 0.05 to 5.0% w/v.
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20. A method according to claim 12, wherein the liquid enzyme cleaning composition comprises an enzyme, 25% glycerol w/v, 50% PEG-400 w/v, 1.5% w/v sodium borate, 0.25% w/v calcium chloride and water.
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21. A method according to claim 20, wherein the enzyme is selected from the group consisting of pancreatin, subtilisin, trypsin and methyl trypsin.
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22. A method according to claim 20, wherein the enzyme is trypsin in the amount of at least 900 PAU/mL.
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23. A method according to claim 20, wherein the enzyme is methyl trypsin in the amount of at least 900 PAU/mL.
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24. A method according to claim 20, wherein the antimicrobial agent comprises 0.00001% to 0.05% w/v of polyquaternium-1.
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25. A method according to claim 12, wherein the antimicrobial agent comprises 0.00001% to 0.05% w/v of polyquaternium-1.
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26. A method according to claim 12, wherein the disinfectant/enzyme solution has an osmolality of from 150 to 350 mOsmoles/kg.
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27. A method according to claim 12, wherein the enzyme is an Al-trypsin.
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28. A method of cleaning a contact lens which comprises:
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forming an aqueous enzymatic cleaning solution by dispersing an amount of a liquid enzyme composition in an aqueous solvent, said liquid enzyme composition comprising a proteolytic enzyme in an amount effective to clean the lens;
40-85% w/v of monomeric polyols and polyalkoxylated glycols, the glycols having a molecular weight between 200-600 daltons;
an amount of a borate/boric acid compound effective to enhance the proteolytic stability of the enzyme;
an amount of calcium ion effective to enhance the proteolytic stability of the enzyme; and
water; and
soaking the lens in the enzymatic cleaning solution for a period of time sufficient to clean the lens. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification
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Current AssigneeAlcon Manufacturing Limited (Alcon Incorporated)
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Original AssigneeAlcon Laboratories Incorporated (Alcon Incorporated)
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InventorsAsgharian, Bahram, Hong, Bor-Shyue
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Primary Examiner(s)Weber, Jon P.
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Application NumberUS09/144,674Time in Patent Office952 DaysField of Search435/188, 510/114, 510/393US Class Current435/188CPC Class CodesC11D 3/0078 Compositions for cleaning c...C11D 3/2044 linearC11D 3/221 Mono, di- or trisaccharides...C11D 3/38618 Protease or amylase in liqu...
