Emulsion for robust sensing
First Claim
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1. A gas sensing composition, comprising:
- a dispersed first phase comprising droplets which are substantially smaller in at least one dimension than the thickness of the sensing composition, wherein the first phase contains at least one substantially water soluble emulsification enhancement agent and at least one water soluble indicator component effective to provide a signal in response to the concentration of a gas in a medium to which the sensing composition is exposed; and
a hydrophobic second phase which is permeable to the analyte and impermeable to ionized hydrogen, wherein the second phase contains at least one substantially water insoluble emulsification enhancement agent;
wherein the water soluble emulsification enhancement agent comprises a nonionic, amphipathic copolymer containing both hydrophilic and hydrophobic moieties.
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Abstract
The present invention provides an optical fluorescence based sensor for measuring the concentration of a gas (e.g., CO2 or ammonia) in a medium such as blood which has superior dry web sensor performance, enhanced sensor consistency for transparent sensor calibration, improved autoclave stability and rapid rehydration of the sensor. In a preferred embodiment, the sensors of the present invention comprise microcompartments of an aqueous phase having a pH sensitive indicator component and a nonionic amphipathic surfactant within a hydrophobic barrier phase comprising a plurality of dispersed hydrophobic particles.
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Citations
29 Claims
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1. A gas sensing composition, comprising:
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a dispersed first phase comprising droplets which are substantially smaller in at least one dimension than the thickness of the sensing composition, wherein the first phase contains at least one substantially water soluble emulsification enhancement agent and at least one water soluble indicator component effective to provide a signal in response to the concentration of a gas in a medium to which the sensing composition is exposed; and
a hydrophobic second phase which is permeable to the analyte and impermeable to ionized hydrogen, wherein the second phase contains at least one substantially water insoluble emulsification enhancement agent;
wherein the water soluble emulsification enhancement agent comprises a nonionic, amphipathic copolymer containing both hydrophilic and hydrophobic moieties. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
a sensing element comprising a sensing composition according to claim 22;
an excitation assembly positioned and adapted to provide an excitation signal to the sensing element;
a detector assembly positioned and adapted to detect an emitted signal from the sensing element, the sensing element being capable of providing the emitted signal in response to being exposed to the excitation signal; and
a processor assembly positioned and adapted to analyze the emitted signal in determining the concentration of the analyte in the medium.
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29. A sensor for measuring the concentration of an analyte in a medium comprising:
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a sensing element comprising a sensing composition according to claim 1;
an excitation assembly positioned and adapted to provide an excitation signal to the sensing element;
a detector assembly positioned and adapted to detect an emitted signal from the sensing element, the sensing element being capable of providing the emitted signal in response to being exposed to the excitation signal; and
a processor assembly positioned and adapted to analyze the emitted signal in determining the concentration of the analyte in the medium.
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Specification
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Current AssigneeTerumo Cardiovascular Systems Corporation (Terumo Corporation)
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Original AssigneeTerumo Cardiovascular Systems Corporation (Terumo Corporation)
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InventorsRueb, Christopher J., Bretscher, Kathryn R., Nguyen, Mai T., Wood, Kenneth B., Baker, James A., Hamer, Monica A.
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Primary Examiner(s)SNAY, JEFFREY R
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Application NumberUS08/943,824Time in Patent Office1,292 DaysField of Search422/82.05, 422/82.06, 422/82.07, 422/82.08, 436/172, 436/164, 436/166, 436/167US Class Current422/82.07CPC Class CodesG01N 31/223 for investigating presence ...G01N 33/4925 measuring blood gas content...G01N 33/84 involving inorganic compoun...
