Compliant tissue sealants
First Claim
1. A compliant polymeric material on a tissue surface, wherein the material is formed by the polymerization of an aqueous solution or suspension of a polymerizable monomer comprising polymerizable groups selected from the group consisting of vinyl groups, allyl groups, cinnamates, amines, alcohols, thiols, sulfonic acid groups and carboxylic acid groups in contact with the tissue surface, andwherein the nornalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3.
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Accused Products
Abstract
An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, the system is compliant, in that it is capable of conforming to the three dimensional structure of a tissue surface as the tissue bends and deforms during healing processes. The barrier or drug delivery systems is formed as a polymeric coating on tissue surfaces by applied a polymerizable monomer to the surface, and then polymerizing the monomer. The polymerized compliant coating preferably is biodegradable and biocompatible, and can be designed with selected properties of compliancy and elasticity for different surgical and therapeutic applications.
428 Citations
23 Claims
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1. A compliant polymeric material on a tissue surface, wherein the material is formed by the polymerization of an aqueous solution or suspension of a polymerizable monomer comprising polymerizable groups selected from the group consisting of vinyl groups, allyl groups, cinnamates, amines, alcohols, thiols, sulfonic acid groups and carboxylic acid groups in contact with the tissue surface, and
wherein the nornalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3.
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12. A method for forming a compliant polymeric material on a tissue surface, the method comprising
applying an aqueous solution or suspension of a polymerizable monomer comprising polymerizable groups selected from the group consisting of vinyl groups, allyl groups, cinnamates, amines, alcohols, thiols, sulfonic acid groups and carboxylic acid groups to the surface; - and
polymerizing the material on the surface;
wherein the normalized compliance ratio of the tissue and the material is in the range of about 0.05 to about 3. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
wherein the method comprises photopolymerizing the monomer on the tissue surface in the presence of a free radical polymerization initiator. -
15. The method of claim 12 wherein the polymerized material has an elongation at rupture which is similar to or greater than the elongation of the tissue in vivo.
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16. The method of claim 12 wherein the polymerized material has an elongation at rupture which is greater than about 100%.
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17. The method of claim 12 wherein the polymerized material has an elastic modulus which is less than about 150 kPa.
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18. The method of claim 12 wherein the material has an adherence to the surface of at least about 20 grams per square centimeter.
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19. The method of claim 12 wherein the material further comprises a biologically active material.
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20. The method of claim 12, wherein the material is biodegradable.
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21. The method of claim 19 wherein the method comprises applying the polymerizable monomer and the biologically active material to the surface of a biological tissue and polymerizing the monomer on the tissue to form a polymeric compliant material on the surface incorporating the biologically active material, wherein the material is capable of controlled release of the biologically active material.
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22. The method of claim 12 wherein the polymerizable monomer is applied to a plurality of surfaces, at least one of said surfaces being a tissue surface, and wherein the polymerization of the material on the surface causes adhering of the surfaces.
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23. The method of claim 13 wherein the compliant polymeric material is formed on the surface of a lung in vivo.
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Specification