×

Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry

  • US 6,218,118 B1
  • Filed: 07/09/1998
  • Issued: 04/17/2001
  • Est. Priority Date: 07/09/1998
  • Status: Expired due to Fees
First Claim
Patent Images

1. A mixture or set of sub-mixtures comprising natural and mass-modified X-mer precursors,wherein said X-mer precursors have a minimum length of 3 nucleotides, wherein said mixture has a minimum mixture coverage complexity of at least 56/N or wherein said set of sub-mixtures has a composite mixture coverage complexity of at least 56/N, wherein N represents the number of distinct X-mer precursors in the mixture, wherein mass number complexity of said mixture is greater than the mass number complexity of any natural equivalent of said mixture or wherein mass number complexity of said set of sub-mixtures is greater than the mass number complexity of any natural equivalent of said set of sub-mixtures, wherein each sub-mixture in said set has a reduced mixture coverage complexity as compared with the composite mixture coverage complexity and wherein each sub-mixture further comprises a plurality of X-mer precursors, wherein said length is selected independently for each X-mer precursor, and wherein each of said X-mer precursors in said mixture is represented by a single chemical species.

View all claims
  • 3 Assignments
Timeline View
Assignment View
    ×
    ×