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Methods of monitoring disease states and therapies using gene expression profiles

  • US 6,218,122 B1
  • Filed: 06/16/1999
  • Issued: 04/17/2001
  • Est. Priority Date: 06/19/1998
  • Status: Expired due to Fees
First Claim
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1. A method of determining a level of one or more disease states in a subject, said method comprising determining, for each of said disease states, one or a combination of interpolated response profiles, extracted from interpolated response curves correlated to levels of each of said disease states, for which similarity is greatest between a diagnostic profile and said determined interpolated response profiles, said diagnostic profile comprising measured amounts of a first plurality of cellular constituents in one or more cells of said subject, and wherein said interpolated response curves are the products of a method comprising(i) providing response profiles of one or more cells of one or more analogous subjects for each of said disease states wherein said response profiles comprise measured amounts of a second plurality of cellular constituents in said cells of said one or more analogous subjects at a plurality of levels for each of said disease states, said second plurality comprising at least a portion of said first plurality, and (ii) interpolating said response profiles so that a response profile may be extracted over a range of levels for each of said disease states, wherein the level of each disease state correlated to each determined interpolated response profile indicates said levels of said disease states.

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