Methods and apparatus for non-invasive glucose sensing: non-invasive probe

• US 6,219,565 B1
• Filed: 12/03/1998
• Issued: 04/17/2001
• Est. Priority Date: 02/05/1996
• Status: Expired due to Fees

• Current Assignee: Dominion Assets LLC
• Original Assignee: Diasense Inc.
• Inventors: Cupp, James, Fowler, Raymond
• Primary Examiner(s): Winakur, Eric F.
• Application Number:
  US09/117,756
• Time in Patent Office: 866 Days
• Field of Search: 600/310, 600/311, 600/316, 600/322, 600/323, 600/342, 600/473, 600/476, 356/39, 385/115
• US Class Current: 600/310
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

Disclosed is a probe 2 suitable for use in the non-invasive sensing of glucose concentrations in the body of a patient. The probe 2 includes at least three radiation receiving fibers 16 extending between a probe body 12 and a spectrograph 8, and spaced apart from each other in a substantially uniform manner and aligned in a predetermined fixed pattern at the probe body 12. A radiation transmitting means 10 conducts radiation from a radiation source 4 and extends from the radiation source 4 to the probe body 12. The radiation transmitting means 10 is formed in the probe 2 into ring means for conducting radiation in a ring-shaped area immediately surrounding each of said receiving fibers 16. The radiation transmitting means 10 and the receiving fibers 16 terminate at the probe body 12 in a unitary structure having an outer surface configured for contacting the skin of a patient. The ring means passes radiation from the radiation source 4 into the patient in the areas immediately surrounding each receiving fiber 16. The receiving fibers 16 detect the radiation passing back out of the patient and pass this detected radiation to the spectrograph 8.

Claims

1. A probe suitable for use in the non-invasive sensing of glucose concentrations in the body of a patient, said probe comprising:

at least three radiation receiving fibers extending between a probe body and a spectrograph, and spaced apart from each other in a substantially uniform manner and aligned in a predetermined fixed pattern at said probe body, a radiation transmitting means for conducting radiation from a radiation source and extending from the radiation source to the probe body, with said radiation transmitting means formed in said probe into ring means for conducting radiation in a ring-shaped area immediately surrounding each of said receiving fibers, with said radiation transmitting means and said receiving fibers terminating at said probe body in a unitary structure having an outer surface configured for contacting the skin of a patient, wherein the ring means passes radiation from said radiation source and into the patient in the areas immediately surrounding each receiving fiber and the receiving fibers detect said radiation passing back out of the patient and pass said detected radiation to the spectrograph.

2. The probe of claim 1 wherein said radiation transmitting means is formed of a plurality of radiation transmitting fibers and the ring means is formed from certain of said transmitting fibers immediately surrounding each receiving fiber in a ring-shaped pattern at the outer surface.

3. The probe of claim 2 wherein each receiving fiber is separated from its immediately adjacent receiving fiber by at least one transmitting fiber.

4. The probe of claim 2 wherein the transmitting fibers at the radiation source are arranged in an incoherent manner.

5. The probe of claim 4 wherein the transmitting fibers at the radiation source are arranged in a hexagonally packed circular pattern.

6. The probe of claim 2 wherein the transmitting fibers are arranged in a plurality of transmitting fiber rings surrounding each receiving fiber, with each ring arranged in a tightly packed hexagonal pattern from said transmitting fibers.

7. The probe of claim 6 wherein the transmitting fiber rings surrounding each receiving fiber share transmitting fibers with one or more transmitting fiber rings of receiving fibers immediately adjacent thereto.

8. The probe of claim 2 wherein the transmitting fibers are arranged in three transmitting fiber rings surrounding each receiving fiber, with each ring arranged in a tightly packed hexagonal pattern from said transmitting fibers.

9. The probe of claim 2 wherein the transmitting fibers and receiving fibers in said probe at said outer surface are affixed together with adhesive.

10. The probe of claim 1 wherein the receiving fibers are arranged in contact with each other and along a straight line at their end opposite the probe body and adjacent the spectrograph.

11. The probe of claim 1 wherein the receiving fibers are covered by an enclosure in the area between an outer portion of the probe body and their termination at the spectrograph.

12. The probe of claim 11 wherein the enclosure includes a first insulating enclosure immediately adjacent the probe body and a second insulating enclosure extending along the remaining length of the receiving fibers.

13. The probe of claim 12 wherein the first insulating enclosure is a hollow structure filled with an insulating material.

14. The probe of claim 12 wherein the second enclosure includes a first insulating tube immediately surrounding the receiving fibers and a second insulating tube spaced from and surrounding the first insulating tube.

15. The probe of claim 14 wherein one end of the second insulating tube is securely attached to the first insulating tube, while the other end of the second insulating tube is loosely attached to the first insulating tube and is moveable with respect thereto.

16. The probe of claim 15 wherein the end of the first insulating tube adjacent the probe body is attached to a slip ring which is attached to the first enclosure and the end of the second insulating tube adjacent the probe body is slip fit onto the slip ring.

17. The probe of claim 16 wherein the ends of the receiving fibers opposite the probe body are securely attached to a receiving fiber housing and the first insulating tube and second insulating tube are each securely attached to the receiving fiber housing.

18. The probe of claim 17 wherein the receiving fiber housing is a hollow structure filled with an insulating material.

19. The probe of claim 14 wherein an interior of the first insulating tube is filled with an elastomeric compound.

20. The probe of claim 1 wherein the radiation receiving fibers are aligned in a substantially straight line.