Device and method for enchancing transdermal sampling
First Claim
Patent Images
1. A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
- a sheet having a plurality of microblades formed from the sheet and bent downward therefrom and at least one opening in the sheet adjacent the plurality of microblades; and
a collector on the sheet which withdraws the agent through the pathways and collects said agent.
2 Assignments
0 Petitions
Accused Products
Abstract
A percutaneous agent sampling device and method are provided. The device comprises a collector and a sheet having a plurality of microblades for piercing the skin for increasing transdermal flux of an agent.
-
Citations
28 Claims
-
1. A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
-
a sheet having a plurality of microblades formed from the sheet and bent downward therefrom and at least one opening in the sheet adjacent the plurality of microblades; and
a collector on the sheet which withdraws the agent through the pathways and collects said agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
a semi-permeable membrane positioned across an opening in the sheet; and
an absorbent pad on the semi-permeable membrane.
-
-
7. The device of claim 6, wherein the absorbent pad contains an osmotically active material.
-
8. The device of claim 1, further comprising an agent sensing element.
-
9. The device of claim 8, wherein the agent sensing element is a glucose sensor.
-
10. The device of claim 1, further comprising an activation mechanism such that when activated, the collector performs a collection and monitoring sequence.
-
11. The device of claim 1, wherein the microblades having a length in the range of about 0.02 mm to about 0.4 mm.
-
12. A method for transdermally sampling an agent contained in the body of a patient, comprising:
-
providing a sheet having at least one opening adjacent a plurality of microblades, said microblades formed from the sheet and bent downward therefrom;
forming a plurality of microslits through a stratum corneum of skin of the patient by placing on the skin the sheet to cause said microblades to pierce the stratum corneum; and
withdrawing the agent through the microslits and collecting the agent in a reservoir. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
-
a sheet having at least one opening adjacent a plurality of microblades extending from the sheet; and
a passive diffusion device on the sheet which collects the agent withdrawn through the pathways. - View Dependent Claims (24)
-
-
25. A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
-
a sheet having at least one opening adjacent a plurality of microblades extending from the sheet; and
an osmotic device on the sheet which collects the agent withdrawn through the pathways. - View Dependent Claims (26)
-
-
27. A device for piercing the stratum corneum of a body surface to form pathways through which an agent can be withdrawn, comprising:
-
a sheet forming at least one opening adjacent a plurality of microblades extending from the sheet; and
a reverse electrotransport device on the sheet which collects the agent withdrawn through the pathways. - View Dependent Claims (28)
-
Specification