Method of using deuterated calcium channel blockers
First Claim
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1. A method of blocking calcium channels with enhanced efficacy in an animal comprising:
- administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R is hydrogen or deuterium and one or more R is deuterium.
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Abstract
Therapeutic methods and compositions using deuterated enriched 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester and other deuterated dihydropyridine compounds are described. The deuterated compounds exhibit enhanced efficacy in blocking calcium channels over non-deuterated dihydropyridines.
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Citations
15 Claims
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1. A method of blocking calcium channels with enhanced efficacy in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R is hydrogen or deuterium and one or more R is deuterium.
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2. A method of blocking calcium channels with enhanced efficacy in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium. - View Dependent Claims (3)
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4. A method of blocking calcium channels with enhanced duration of action in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R is hydrogen or deuterium and one or more R is deuterium.
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5. A method of blocking calcium channels with enhanced duration of action in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium. - View Dependent Claims (6)
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7. A method of blocking calcium channel with enhanced use dependence in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R is hydrogen or deuterium and one or more R is deuterium.
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8. A method of blocking calcium channels with enhanced use dependence in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium. - View Dependent Claims (9)
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10. A method of treating hypertension with enhanced efficacy in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R is hydrogen or deuterium and one or more R is deuterium.
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11. A method of treating hypertension with enhanced efficacy in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium. - View Dependent Claims (12)
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13. A method of treating hypertension with an extended duration of action in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R is hydrogen or deuterium and one or more R is deuterium.
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14. A method of treating hypertension with an extended duration of action in an animal comprising:
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administering to an animal in need thereof, an effective amount of an enriched calcium channel blocking compound of the following structure;
wherein R and R1 are hydrogen or deuterium and one or more R1 is deuterium. - View Dependent Claims (15)
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Specification