Antisense oligonucleotide compositions and methods for the modulation of JNK proteins
First Claim
1. An oligonucleotide comprising up to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence which specifically binds to a 3′
- -untranslated region, an open reading frame region, or a translation initiation region of a nucleic acid encoding JNK1 protein (SEQ ID NO;
164), a homolog of JNK1 (SEQ ID NO;
165) or an alpha-2 (SEQ ID NO;
166), beta-1 (SEQ ID N;
167) or beta-2 (SEQ ID NO;
168) isoform thereof, and wherein said oligonucleotide modulates the expression of said JNK1 protein, said JNK1 homolog or said isoform thereof.
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Accused Products
Abstract
Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a gene encoding a Jun N-terminal kinase (JNK protein) are provided. Oligonucleotide are herein provided which are specifically hybridizable with nucleic acids encoding JNK1, JNK2 and JNK3, as well as other JNK proteins and specific isoforms thereof. Methods of treating animals suffering from diseases or disorders amenable to therapeutic intervention by modulating the expression of one or more JNK proteins with such oligonucleotide are also provided. Methods for the treatment and diagnosis of diseases or disorders associated with aberrant expression of one or more JNK proteins are also provided. The invention is thus directed to compositions for modulating, diagnostic methods for detecting, and therapeutic methods for inhibiting, the hyperproliferation of cells and formation, development and maintenance of tumors.
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Citations
23 Claims
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1. An oligonucleotide comprising up to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence which specifically binds to a 3′
- -untranslated region, an open reading frame region, or a translation initiation region of a nucleic acid encoding JNK1 protein (SEQ ID NO;
164), a homolog of JNK1 (SEQ ID NO;
165) or an alpha-2 (SEQ ID NO;
166), beta-1 (SEQ ID N;
167) or beta-2 (SEQ ID NO;
168) isoform thereof, and wherein said oligonucleotide modulates the expression of said JNK1 protein, said JNK1 homolog or said isoform thereof. - View Dependent Claims (2, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- -untranslated region, an open reading frame region, or a translation initiation region of a nucleic acid encoding JNK1 protein (SEQ ID NO;
-
3. An oligonucleotide comprising up to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence which specifically binds to a JNK2 homolog (SEQ ID NO:
- 170) or an alpha-1 (SEQ ID NO;
171), beta-1 (SEQ ID NO;
172) or beta-2 (SEQ ID NO;
173) isoform thereof and wherein said oligonucleotide inhibits the expression of said JNK2 protein, said JNK2 homolog or said isoform thereof.
- 170) or an alpha-1 (SEQ ID NO;
-
4. An oligonucleotide comprising up to 30 nucleotides connected by covalent linkages, wherein said oligonucleotide has a sequence which specifically binds to a 3′
- -untranslated region, an open reading frame region, a 5′
-untranslated region or a translation initiation region of a nucleic acid encoding a JNK3 protein (SEQ ID NO;
174), a JNK3 homolog (SEQ ID NO;
175 or SEQ ID NO;
176) or an alpha-1 (SEQ ID NO;
177) or alpha-2 (SEQ ID NO;
178) isoform thereof and wherein said oligonucleotide modulates the expression of said JNK3 protein, said JNK3 homolog or said isoform thereof.
- -untranslated region, an open reading frame region, a 5′
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23. An antisense oligonucleotide up to 30 nucleobase in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40 or 41, wherein said antisense oligonucleotide inhibits JNK2 protein expression.
Specification