Method for increasing the concentration of ascorbic acid in brain tissues of a subject

• US 6,221,904 B1
• Filed: 11/19/1999
• Issued: 04/24/2001
• Est. Priority Date: 05/21/1997
• Status: Expired due to Fees

• Current Assignee: Sloan-Kettering Institute For Cancer Research (Memorial Sloan-Kettering Cancer Center)
• Original Assignee: Sloan-Kettering Institute For Cancer Research (Memorial Sloan-Kettering Cancer Center)
• Inventors: Agus, David B., Golde, David W., Vera, Juan C.
• Primary Examiner(s): Reamer, James H.
• Application Number:
  US09/443,785
• Time in Patent Office: 522 Days
• Field of Search: 514/474
• US Class Current: 514/474
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/34 having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• CPC Class Codes: A61K 31/375 Ascorbic acid, i.e. vitamin C; Salts thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

This invention provides a method for increasing the ascorbic acid concentration in brain tissues of a subject which comprises administering to the subject an amount of dehydroascorbic acid effective to increase the concentration of ascorbic acid in brain tissues. This invention also provides that the dehydroascorbic acid enters the tissues through the facilitative glucose transporter.

Claims

1. A method of treating or preventing a disease or order in a subject which comprises administering to the subject an amount of dehydroascorbic acid or a salt thereof effective to increase the concentration of ascorbic acid in the subject'"'"'s brain tissue, wherein the disease or order is selected from the group consisting of a neurodegenerative disease, a neurovascular disease, a disease which involves the oxidative modification of lowdensity lipoprotein or lipid perioxidation, a behavior disorder, dementia, Huntington'"'"'s Disease and schizophrenia, so as to thereby treat or prevent a disease or order in the subject.

3. The method of claim 1 or 2, wherein the subject is a human being.

4. The method of claim 1 or 2, wherein the neurodegenerative disease is Alzheimer'"'"'s Disease or Parkinson'"'"'s disease.

5. The method of claim 1 or 2, wherein the neurovascular disease is stroke.

6. The method of claim 1 or 2, wherein the disease which involves the oxidative modification of low-density lipoprotein or lipid perioxidation is stroke, atherosclerosis or a neurodegenerative disorder.

7. The method of claim 1 or 2, wherein the behavioral disorder is dysthymia, involution depression, aggressiveness via dominance, hyperactivity, deprivation syndrome, separation anxiety, intermittent anxiety, instrumental sociopathy, stereotypies, phobia or a socialization disorder.

8. The method of claim 1 or 2, wherein the dehydroascorbic acid is administered orally, intravenously, subcutaneously, intramuscularly or liposome-mediated delivery.

9. The method of claim 1 or 2 which further comprises administering an effective amount of a therapeutic agent.

2. A method of treating or preventing a disease or order in a subject which comprises administering to the subject an amount of dehydroascorbic acid or a salt thereof effective to increase antioxidant potential of the subject'"'"'s brain tissue, wherein the disease or order is selected from the group consisting of a neurodegenerative disease, a neurovascular disease, a disease which involves the oxidative modification of lowdensity lipoprotein or lipid perioxidation, a behavior disorder and dementia, Huntington'"'"'s Disease and schizophrenia, so as to thereby treat or prevent a disease or order in the subject.